objective: hepatitis c virus (hcv) is one of the most relevant persistent infections afflicting the human population. control of viral replication in hcv infection has been associated with the cellular component of the host immune response. several mechanisms have been proposed to explain this abnormal immune response, among them an altered activity of regulatory t cells (tregs) being the most ...

First discovered... The existence of T regulatory cells was first suggested by several animal models in the 1970s. Organ-specific autoimmunity was found to be induced in specific strains of mice that had been thymectomized 3 days after birth but not after thymectomy at 0 or 7 days. It was proposed that self-reactive T cells emerged from the thymus immediately after birth but that there existed ...

During the past 2 decades, human and animals studies have clearly documented the crucial role of inflammation in the development and complications of atherosclerosis. Both innate immunity and adaptive immunity are involved in this process. The first evidence that suggested a role of adaptive immunity in atherosclerosis was the widespread detection of the major histocompatibility class II in hum...

Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease...

CD4+ regulatory (Treg) T cells play a central role in the immune system by potently controlling the responses of other immunocytes. Their activity appears to be essential not only for themaintenanceof immunological self-tolerancebut potentially also for the control of all physiological immune responses whether against normal self-proteins, microbes or cancerous cells. A fuller understanding of ...

Since Gowans first discovered the importance of lymphocytes in the immune response [1], a gradual understanding of their biology has evolved. Initially, B lymphocytes, the effector cells of humoral immunity, were studied in great detail. Largely because of the ability to obtain huge quantities of homogeneous antibodies-the B cell's primary product-through the study of multiple myeloma, tremendo...