Food, drug, and cosmetic dyes of the xanthane type (analogs of fluorescein) were applied to isolated molluscan ganglia and changes in the electrophysiological properties of identified neurons were monitored. The synthetic coloring agents increased the resting membrane potential and conductance of the neurons in a dose-dependent manner by increasing the potassium permeability of the membrane rel...

Objectives: This study was conducted to investigate marginal adaptation, compressive strength, water sorption, solubility, fluoride and calcium release of a claimed bioactive restorative material (ACTIVA BioACTIVE Restorative) compared glass ionomer (Fuji IX) resin composite (SphereTEC). Materials methods: ACTIVA evaluated relative Fuji IX SphereTEC one. Marginal gap width detected via scanning...

Sustainability of agricultural systems is at stake, as phosphorus (P) a non-renewable resource while its global reserves are limited. Stimulating earthworm activity can be technology to increase the level readily plant-available phosphate (PO4). However, conclusive evidence on mechanisms underlying an earthworm-enhanced PO4 solubility yet missing. This study aimed reveal possibly overlooked pat...

objective: the purpose of this study was to evaluate the solubility of three luting cements in artificial saliva. materials and methods: twenty disks (10×4 mm) of polycarboxylate, zinc phosphate and glass ionomer cements were prepared according to manufactures’ instructions. after setting, they were desiccated and each ten specimens were immersed in artificial saliva with special ph (3 or 5), c...

the solubility of naproxen in binary mixtures of polyethylene glycol 200 (peg 200) + water at the temperature range from 298.0 k to 318.0 k were reported. the combinations of jouyban-acree model + van’t hoff and jouyban-acree model + partial solubility parameters were used to predict the solubility of naproxen in peg 200 + water mixtures at different temperatures. combination of jouyban-acree m...

Although they are both highly polar liquids, there are a number of compounds, such as many pharmaceuticals, which show vastly different solubilities in methanol compared with water. From theories of the hydrophobic effect, it might be predicted that this enhanced solubility is due to association between drugs and the less polar -CH3 groups on methanol. In this work, detailed analysis on the ato...

Camptothecin were first introduced in the early 1970’s, formulated in sodium hydroxide to enhance solubility, in clinical trials but was terminated due to a lack of clinical antitumor activity and a significant incidence of hemorrhagic diarrhea and uroepithelial toxicity [1]. These unexpected toxicities are believed to have been due to instability of camptothecin, which exists as biologically i...

The maintenance of protein solubility is a fundamental aspect of cellular homeostasis because protein aggregation is associated with a wide variety of human diseases. Numerous proteins unrelated in sequence and structure, however, can misfold and aggregate, and widespread aggregation can occur in living systems under stress or aging. A crucial question in this context is why only certain protei...

Chemical modification of small molecule hydrophobic drugs is a clinically proven strategy to devise prodrugs with enhanced treatment efficacy. While this prodrug strategy improves the parent drug's water solubility and pharmacokinetic profile, it typically compromises the drug's potency against cancer cells due to the retarded drug release rate and reduced cellular uptake efficiency. Here we re...

Soil incubations are a common practice typically employed in assessing the effect of some treatment on the availability and solubility of phosphorus (P). However, standard sample preparation (drying and sieving) can alter soil chemical and physical properties, resulting in possible changes in P behavior upon soil incubation. Sixty surface soil samples were collected, air dried, and sieved befor...