background: neurotransmitter release is an essential link in cell communication of the nervous system. many investigations have focused on gamma amino butyric acid (gaba)-ergic neurotransmission, because it has been implicated in the pathophysiology of several central nervous system disorders. to bypass complications related to homo- and heterosynaptic modulation and to avoid indirect interpret...

The high-density gastroretentive dosage forms was made a theophylline tablets 250 mg by wet granulation method in three formulas with combine the polymer concentration. used sodium alginate and PVP K30, where 1st formula ratio of alginate: K30 (18.75%: 5%), 2nd 2, 5%) 3th (12.5%: 2.5%). third were evaluated weight uniformity test, size hardness drug content vitro release as well determination k...

Objective(s): Researchers have intended to reformulate drugs so that they may be more safely used in human body. Polymer science and nanotechnology have great roles in this field. The aim of this paper is to introduce an efficient drug delivery vehicle which can perform both targeted and controlled antibiotic release using magnetic nanoparticles grafted pH-responsive polymer.<s...

objective (s): mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.materials and methods:everydiscs containing 70 mg stem bark extract of ziziphus jujuba were formulated  by using carbopol 934, pvp k30 and gelatin as polymers. discs were made by granulation  and direct compression. discs were standardized based on the total phenol.  properties such as in vi...

the aim of the present work was to prepare and characterize biopolymer nanocarriers and evaluate their suitability in possible oral delivery of insulin. the egg albumin biopolymer was used to prepare nanoparticles which were further characterized by fourier transformed infrared spectroscopy (ftir), transmission electron microscopy (tem), scanning electron microscopy (sem), zeta potential, dynam...

The effects of nanoparticle (NP) properties, such as size, shape and surface charge, on their efficacy and toxicity have been studied extensively. However, the effect of controlled drug release on NP efficacy and toxicity has not been thoroughly evaluated in vivo. Our study aims to fill this knowledge gap. A key challenge in characterizing the relationship between drug release and therapeutic r...

The internal microstructure of a tablet, such as pore geometry and volume, impacts the tablet’s disintegration kinetics. Ideally, one could design to control dissolution onset therapeutical performance immediate-release formulas; however, manufacturing tablets with desired can be challenging due interplay between formulation process parameters. Direct quantification tablet provide framework for...