The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.

introduction: acute renal failure is a common consequence of sepisis due to concurrent renal ischaemia. the role of nitric oxide (no) in endotoxaemia and in ischaemic injury in the kidney is not well defined. material and methods: in this study we have used an animal model of sepsis induced by injection of bacterial lipopolysaccharide (lps) in the rat and measured renal nitric oxide by x-band e...

Renal injury is a common clinical problem in the critically ill patient, and is associated with poor outcome [1,2]. Two large multicentre cohort studies reported previously the occurrence of renal injury in an estimated 30-40% of all patients admitted to the ICU [3,4]. Furthermore, critically ill patients who develop renal injury and require renal replacement therapy, have mortality rates of 50...

Cisplatin is used as a treatment for various types of solid tumors. Renal injury severely limits the use of cisplatin. Renal cell apoptosis, oxidative stress, and inflammation contribute to cisplatin-induced nephrotoxicity. Previously, we found that an extract of Rhodobacter sphaeroides (Lycogen™) inhibited proinflammatory cytokines and the production of nitric oxide in activated macrophages in...

Combined acute renal and pulmonary failure has a very high mortality. In animals, lung injury develops after shock or visceral or renal ischemia. Alpha-melanocyte-stimulating hormone (alpha-MSH) is an antiinflammatory cytokine, which inhibits inflammatory, apoptotic, and cytotoxic pathways implicated in acute renal injury. We sought to determine if alpha-MSH inhibits acute lung injury after ren...

 ABSTRACT COVID-19 mainly affects respiratory and immune systems, but other organs like renal, cardiovascular, lung and nervous systems could also be involved in both acute and chronic settings (1, 2). There is a lot of studies that demonstrate an increasing number of long COVID-19 who continue to experience persistent symptoms weeks or even months after the initial disease. Reports suggest...

OBJECTIVE The objective of the study was to assess urinary biomarkers of renal injury for their individual or collective ability to predict Worsening renal function (WRF) in patients with acutely decompensated heart failure (ADHF). METHODS In a prospective, blinded international study, 87 emergency department (ED) patients with ADHF were evaluated with biomarkers of cardiac stretch (B type na...

Purpose: To investigate the effects of cyclosporine A on renal ischemia-reperfusion injury during transient hyperglycemia in rats. Methods: In a model of ischemia-reperfusion-induced renal injury and transiently induced hyperglycemia by intraperitoneal injection of glucose, 2.5 g.kg-1, Wistar rats were anesthetized with either isoflurane or propofol and received intravenous cyclosporine A, 5...

Combined acute renal and pulmonary failure has a very high mortality. In animals, lung injury develops after shock, or visceral or renal ischemia. -Melanocyte stimulating hormone ( MSH) is an anti-inflammatory cytokine which inhibits inflammatory, apoptotic, and cytotoxic pathways implicated in acute renal injury. We sought to determine if -MSH inhibits acute lung injury following renal ischemi...

The incidence of injury to the urologic system after trauma is about 10%. Blunt trauma followed by traffic accidents and during sports comprise 90% of the etiologies. In addition, the rate of penetrating injuries is increasing, especially in urban areas. The kidney is the most common urologic organ to be injured, followed by urinary bladder and the urethra. Isolated urologic trauma is rare; the...