S U M M A R Y Since W. J. Morgan proposed that intraplate volcanism at some Pacific hotspots is caused by hot plumes rising from the lower mantle, geophysicists have been actively pursuing physical evidence for mantle plumes. Several seismic studies have mapped low-velocity anomalies below a number of hotspots. However, the association of low-velocity structures with plume tails has remained co...

Natural killer cells are cytotoxic lymphocytes important in immune responses to cancer and multiple pathogens. However, chronic activation of NK cells can induce a hyporesponsive state. The molecular basis of the mechanisms underlying the generation and maintenance of this hyporesponsive condition are unknown, thus an easy and reproducible mechanism able to induce hyporesponsiveness on human NK...

β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. Besides the pre-TCR, β-selection also requires co-stimulatory signals from Notch receptors - key cell fate determinants in eukaryotes. Here, we show that this Notch-dependence is establi...

This paper addresses an approximation-based anti-windup (AW) control strategy for suppressing the windup effect caused by actuator saturation nonlinearity in proportional–integral–derivative (PID) controlled systems. The effect of actuator constraint is firstly regarded as a disturbance imported to the PID controller. The external disturbance can then be modeled by a linear differential equatio...

Both humans and mice with a mutation in the autoimmune regulator (aire) gene develop multiorgan autoimmune disease. Aire was shown to exert its critical function in medullary epithelial cells of the thymus by promoting ectopic expression of peripheral tissue antigens. It was hypothesized that the widespread autoimmunity of Aire-deficient individuals reflects a lack of tolerance induction to the...

Exploring further the properties of ITRM -recognizable reals started in [Ca], we provide a detailed analysis of recognizable reals and their distribution in Gödels constructible universe L. In particular, we show that new unrecognizables are generated at every index γ ≥ ω ω . We give a machine-independent characterization of recognizability by proving that a real r is recognizable iff it is Σ1-...

Phytoextraction may be applied at field scale when the removal of bioavailable metals is the specific target of the technology. Residual metals in soil can be considered substantially inert or to be evaluated by site specific risk analysis.

Employees increasingly use cloud services of third party providers to efficiently perform their job. Interestingly, the majority adopts the cloud without approval of the organization. IT resources like that are commonly referred to as shadow IT. Although widespread in practice, the present literature on shadow IT is scarce lacking a clear definition of the phenomenon and exclusively focusing on...