In the rat, urinary concentrating ability develops progressively during the third postnatal (P) week and nearly reaches adult level at weaning (P21) governed by a rise in circulating glucocorticoid. Elevated extracellular osmolality can lead to growth arrest of epithelial cells. We tested the hypothesis that supranormal exposure of rat pups to glucocorticoid before the endogenous surge enhances...

This study examined the effects of anti-TGF-β antibody (1D11) therapy in Dahl S (S) rats fed a 4% NaCl diet. Baseline renal expression of TGF-β1 and the degree of injury were lower in female than male S rats maintained on a 0.4% NaCl diet. 4% NaCl diet increased mean arterial pressure (MAP), proteinuria, and renal injury to the same extent in both male and female S rats. Chronic treatment with ...

Göransson, V. 2001. Hyaluronan and Renal Fluid Handling. Studies during Normal and Pathological Conditions of Renal Function. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1090. 62 pp. Uppsala. ISBN 91-554-5146-2 The kidney is the major organ responsible for the regulation of the composition and volume of the body fluids, which is ...

Adult Ren-2 gene transgenic rats, TGR(mRen-2)27, exhibit elevated circulating and kidney angiotensin II (Ang II) levels in the presence of severe hypertension. The aim of this study was to examine whether AT1 and AT2 receptors in the kidney and renal hemodynamic and tubular responses to blockade of these receptors were altered in the Ren-2 gene transgenic rats during the maintenance phase of hy...

In 1966, BARBARO and ZvAIFLER [l] demonstrated the release of histamine from rabbit platelets during an acute allergic response. Five years later, it was shown that a soluble factor from leucocytes, capable of inducing platelet activation, was responsible for this effect [2, 3). In subsequent years, the factor was recognized for its potent ability to s timulate platelet aggregation and secretio...