Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide, presenting a great challenge to the public health systems due to high morbidity and mortality, because of frequent micro-/macro-vascular complications. Many treatment options are now available, with different efficacy as well as mechanisms of action to improve deranged glucose metabolism. We review some of the...

The purpose of this article was to prepare and optimize the ingredients of Repaglinide tablets. The impacts of ingredients (diluents, disintegrants and lubricants) content on tablets were evaluated. The optimum prescription contained Repaglinide, meglumine, poloxamer, MCC, maize starch, PVPP, magnesium stearate and appropriate PVP K30.The tablets were evaluated by Carr’s index, hardness, friabi...

Two stability indicating UV-spectrophotometric methods were developed and validated for the determination of repaglinide with its degradation products. Assay of repaglinide in 0.1M NaOH and 0.1M HCl were achieved at 216nm and 243nm respectively. The correlation was in the range of 1.0 – 25 μg mL (r = 0.9999) for 0.1M NaOH and 2.0 – 40 μg mL (r = 0.9999) for 0.1M HCl with molar absorptivity valu...

two sensitive spectrophotometric methods are presented for the assay of repaglinide in bulkdrug and in formulations using methyl orange, as reagents. oxidant by reacting with a fixedamount of either methyl orange and measuring the absorbance at 485.2 nm (method-i) andmeasuring the absorbance at 618.9 nm (method-ii). developed method is based on the formationof extractable colored complex of dru...

Two sensitive spectrophotometric methods are presented for the assay of Repaglinide in bulkdrug and in formulations using methyl orange, as reagents. Oxidant by reacting with a fixedamount of either methyl orange and measuring the absorbance at 485.2 nm (method-I) andmeasuring the absorbance at 618.9 nm (method-II). Developed method is based on the formationof extractable colored complex of dru...

Metformin is the cornerstone of treatment early in the course of type 2 diabetes. Recent studies also provide evidence for the benefits of metformin when given late in the course of the disease, after the introduction of insulin.1 2 However, because metformin targets insulin resistance in overweight patients, can it be as beneficial in non-obese patients? In the linked randomised controlled tri...

The ATP-sensitive K(+) (KATP) channel is an emerging pathway in the skeletal muscle atrophy which is a comorbidity condition in diabetes. The "in vitro" effects of the sulfonylureas and glinides were evaluated on the protein content/muscle weight, fibers viability, mitochondrial succinic dehydrogenases (SDH) activity, and channel currents in oxidative soleus (SOL), glycolitic/oxidative flexor d...

For pediatric patients with hepatocyte nuclear factor-1A (HNF1A)– maturity-onset diabetes of the young (MODY 3), treatment with sulfonylureas is recommended. In adults with HNF1A-MODY, meglitinide analogues achieve lower postprandial glucose levels and pose a lower risk of delayed hypoglycemia compared with sulfonylureas. This therapy has not yet been reviewed in pediatric patients. We report o...

OBJECTIVE We performed a systematic review to identify which genetic variants predict response to diabetes medications. RESEARCH DESIGN AND METHODS We performed a search of electronic databases (PubMed, EMBASE, and Cochrane Database) and a manual search to identify original, longitudinal studies of the effect of diabetes medications on incident diabetes, HbA1c, fasting glucose, and postprandi...