BACKGROUND The effects of moclobemide on damaged ovarian tissue induced by ischemia- reperfusion and damaged contralateral ovarian tissue were investigated in rats, biochemically and histologically. MATERIALS AND METHODS In this experimental study, 40 rats were equally divided into four groups: 10 mg/kg moclobemide, 20 mg/kg moclobemide, ischemia/reperfusion control, and intact control groups...

Background. Endothelin-1 (ET-1) is implicated in left ventricular dysfunction after ischaemia-reperfusion. ETA and ETB receptors mediate diverse actions, but it is unknown whether these actions depend on ischaemia type and duration. We investigated the role of ETB receptors after four ischaemia-reperfusion protocols in isolated rat hearts. Methods. Left ventricular haemodynamic variables were m...

The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling. This hypothesis was studied in isolated perfused rat hearts (measuring infarct size to area of risk [%]) subjected to 35 minutes regional myocardi...

conclusions the results suggest the important role of the antioxidant system potentiation in the prevention of myocardial damage. results cell degenerative changes, pyknotic nuclei, contraction bands, edema, and loosening of collagen in between muscle fibers were observed during ischemia-reperfusion. myocardial architecture and cellular morphology were recovered in co-administration groups, esp...

Reperfusion of ischemic myocardium is essential for tissue salvage but paradoxically contributes to cell death. We hypothesized that activation of potential survival pathways such as p42/p44 MAPK may prevent lethal reperfusion injury. Urocortin is a peptide factor that affects the p42/p44 MAPK signaling pathway. Both isolated and in vivo rat heart models were used to examine the potential for u...

Background: The study of possible ways effective correction retinal ischemia-reperfusion injury, which accompanies a number eye diseases, is relevant today. aim the study: To retinoprotective effect and antiapoptotic mechanism 2-Ethyl-3-hydroxy-6-methyl-pyridine-N-acetyltaurinate (EHMP-NAT) in rat model ischemia–reperfusion (I/R). Materials methods: A pathology with an increase intraocular pres...

introduction: it has been reported that traumas such as transverse abdominal incision before myocardial ischemia result in a significantly decreased infarct size. this phenomenon is named remote preconditioning of trauma. since small skin burn is one of most common traumas, the effect of this injury on ischemia-induced arrhythmias and infarct size was investigated in a rat model of ischemia-rep...

OBJECTIVE Ischemia reperfusion injury is partly responsible for the high mortality associated with induced myocardial injury and the reduction in the full benefit of myocardial reperfusion. Remote ischemic preconditioning, perconditioning, and postconditioning have all been shown to be cardioprotective. However, it is still unknown which one is the most beneficial. To examine this issue, we use...

With secure and dependable antihypertensive effects, telmisartan is an antihypertensive drug. Telmisartan was reported showing distinct neuroprotective effect in cerebral IR injury but the underlying mechanisms are still unclear. The aim of this study was to evaluate the effect of telmisartan prevents cerebral ischemia-reperfusion (I/R) injury-mediated oxidative stress and inflammation in model...