Mediastinoscopy is a safe and simple endoscopic procedure for the exploration of the superior mediastinum. It provides useful information as to the possible resectability of bronchogenic carcinoma, or for establishing the diagnosis of primary tumors of the mediastinum, metastatic disease and a variety of chronic granulomata.

The definition and management of borderline resectability for periampullary pancreatic adenocarcinoma are evolving. In this case report, we discuss the presentation, workup, and therapeutic management of a 40-year-old man who presented with borderline resectable, periampullary pancreatic cancer and underwent a margin-negative resection following neoadjuvant chemoradiotherapy.

Background and study aim. Pancreatic surgery remains complex, particularly for borderline resectable locally advanced tumours. Vascular invasion compromises resectability, vascular resection entails increased morbidity mortality. Following a feasibility safety demonstration of an augmented endoscopic ultrasound (EUS) guided radiofrequency ablation (RFA) using hydroxyethyl starch (HES) in porcin...

INTRODUCTION Oesophagectomy for cancer is associated to a significant morbidity and mortality. The superiority of transthoracic vs transhiatal is still a matter of controversy. The aim of this paper is to discuss the results of a series of patients submitted to either a transthoracic or a transhiatal according to the anatomic location regarding the carina. MATERIAL AND METHODS Retrospective a...

Pancreatic cancer still remains a challenge for surgeons. The goal of surgery is to ensure oncological R0 resection as positive resection margin is associated with poor prognosis. The purpose of this study is to determine the utility of age, ASA score, bilirubin and albumin value, CA 19-9 and imaging modalities for predicting the resectability in pancreatic cancer. This retrospective study cons...

PURPOSE DNA mismatch repair (MMR) is critical in maintaining genomic stability and may modulate the cellular response to gemcitabine. We hypothesized that genetic variations in MMR may affect the clinical outcome of patients with pancreatic cancer. PATIENTS AND METHODS We evaluated 15 single-nucleotide polymorphisms (SNPs) of eight MMR genes in 154 patients with potentially resectable pancrea...

Background Diagnostic imaging plays a critical role in the initial diagnosis and therapeutic monitoring of pancreatic adenocarcinoma. Over the past decade, the concept of 'borderline resectable' pancreatic cancer has emerged to describe a distinct subset of patients existing along the spectrum from resectable to locally advanced disease for whom a microscopically margin-positive (R1) resection ...

Abstract Background Metastasectomy is probably underused in metastatic colorectal cancer. The aim of this study was to investigate the effect centralized repeated assessment on resectability rate liver metastases. Methods prospective RAXO a nationwide Finland. Patients with treatable cancer at any site were eligible. This planned substudy included patients baseline metastases between 2012 and 2...