BACKGROUND The aging of the workforce, coupled with the changing nature of career tenure has raised questions about the impact of these trends on work disability. This study aimed to determine if age and tenure interact in relating to work disability duration. METHODS Relationships were investigated using random effects models with 239,359 work disability claims occurring between 2008 and 201...

on ketamine requirement. Following atropine premedication ketamine 5 mg lb" was administered i.m. They found that i.v. supplementation was required to prevent limb movement before surgery in 70% of patients less than 1 year of age and showed that i.v. ketamine requirements for surgical anaesthesia were associated with age, weight and surface area, age being most significant: i.v. ketamine (ng l...

We assessed the high incidence of pain after injection of methohexitone while conducting recent studies in out-patients using methohexitone and alfentanil. We tried a combination of two methods of solution of mcthohexitone alter reports that the use of normal saline rather than water reduced thc incidence of pain from 42"; to 16",,,' and that pretreatment with lignocaine 10 mg rcduced the incid...

Measurement of the acute hypoxic ventilatory response (AHVR) requires careful choice of the hypoxic stimulus. If the stimulus is too brief, the response may be incomplete; if the stimulus is too long, hypoxic ventilatory depression may ensue. The purpose of this study was to compare three different techniques for assessing AHVR, using different hypoxic stimuli, and also to examine the between-d...

Immaturity of respiratory controllers in preterm infants dispose to recurrent apnea and oxygen deprivation. Accompanying reductions in brain oxygen tensions evoke respiratory depression, potentially exacerbating hypoxemia. Central respiratory depression during moderate hypoxia is revealed in the ventilatory decline following initial augmentation. This study determined whether the thalamic paraf...

BACKGROUND Opioid-induced immobilization is associated with severe respiratory depression in the white rhinoceros. We evaluated the efficacy of butorphanol and oxygen insufflation in alleviating opioid-induced respiratory depression in eight boma-managed rhinoceros. RESULTS Chemical immobilization with etorphine, azaperone and hyaluronidase, as per standard procedure for the white rhinoceros,...

Mice were pretreated either acutely or chronically with morphine to test the effect of such pretreatments on the antagonism by naloxone of morphine-induced respiratory depression and analgesia and to compare the development of tolerance to the two effects. A s.c. injection of 20 mg/kg of morphine 6 hr before testing produced a shift of the apparent pA2 of morphine-naloxone for analgesia from 7....

The Maugeri Respiratory Failure (MRF-28) and Severe Respiratory Insufficiency (SRI) questionnaires were recently developed to assess health-related quality of life (HRQoL) in patients with chronic respiratory failure, although not exclusively in chronic obstructive pulmonary disease (COPD) patients. The aim of the present study was to investigate whether the MRF-28 and SRI are reliable and vali...

Hypoglycemia can cause brain dysfunction, brain injury, and death. The present study seeks to broaden current information regarding mechanisms of hypoglycemic brain injury by investigating a novel etiology. The cat's high resistance to brain injury from hypoglycemia suggested that additional influences such as respiratory depression might play a facilitating role. Three groups of cats were expo...

WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death [see Warnings, Drug Interactions].  Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.  Limit dosages and durations to the minimum required.  Follow patie...