Benzodiazepine drugs may impair breathing during sleep, leading to the development of sleep-disordered breathing or, in subjects with sleep apnoea, an increase in the severity of pre-existing apnoeas. Flumazenil is a selective benzodiazepine-antagonist. We hypothesized that endogenous ligands of benzodiazepine receptors might contribute to the pathogenesis of obstructive sleep apnoea syndrome (...

s from these articles were assessed by 2 reviewers to determine whether they met inclusion criteria. However, if there were any questions on whether the abstract met the inclusion criteria, the article was reviewed in detail to determine whether to accept or reject. Articles were included for evaluation if they focused on treatment of snoring and/or OSA with OAs, and included only adult subject...

Hillsborough County, Florida, is a karst region that is heavily urbanized, yet no study has been undertaken measuring the degree of human disturbance. Van Beynen and Townsend (2005) created a hierarchical and standardized disturbance index specifically designed for karst environments. To address the problem of determining human disturbance in the county, the above index was successfully applied...

OBJECTIVE To determine if patients with nonarteritic ischemic optic neuropathy (NAION) have sleep apnea syndrome (SAS), an entity characterized by repetitive upper airway obstructions during sleep, inducing hypoxia and sleep disruption. METHODS We recruited 17 patients with NAION and 17 age- and sex-matched controls from patients referred for treatment because of suspected restless legs syndr...

BACKGROUND This study was undertaken to establish the prevalence of, and the factors contributing towards, sleep disordered breathing in patients with quadriplegia. METHODS Forty representative quadriplegic patients (time since injury > 6 months, injury level C8 and above, Frankel category A, B, or C; mean (SE) age 35.0 (1.7) years) had home sleep studies in which EEG, EOG, submental EMG, bod...

BACKGROUND AND OBJECTIVES Children with cystic fibrosis (CF) often report poor sleep, increased daytime sleepiness, and fatigue. The purpose of this study was to identify respiratory patterns over the spectrum of disease severity in children with CF. The overall hypothesis for the current study is that children with CF compared with snoring control subjects demonstrate gas exchange abnormalitie...

BACKGROUND Recent studies in children have demonstrated that frequent occurrence of parasomnias is related to increased sleep disruption, mental disorders, physical harm, sleep disordered breathing, and parental duress. Although there have been several cross-sectional and clinical studies of parasomnias in children, there have been no large, population-based studies using full polysomnography t...

Synoptic-scalemonsoon disturbances produce themajority of continental rainfall in themonsoon regions of South Asia and Australia, yet there is little understanding of the conditions that foster development of these low pressure systems. Here a genesis index is used to associate monsoon disturbance genesis in a global domain with monthly mean, climatological environmental variables. This monsoon...