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Thiamine Responsive megaloblastic anemia in DIDMOA (Wolfram) syndrome has an autosomal- recessive mode of inheritance . Megaloblastic anemia and sideroblastic anemia is accompanied by diabetes insipidus (DI), diabetes mellitus (DM) ,optic atrophy (OA) and deafness (D). Neutropenia and thrombocytopenia are also present. We report a 7 month old girl with congenital macrocytic anemia a rare clin...
a novel type of brainstem-predominant encephalomyelitis was first described as chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (clippers) in 2010 by pittocket al and then few additional patients were reported. here we report a 50-year-old iranian male who presented with a number of clinical features described as typical for clippers. the association...
in this study, poly(ethylene-co-vinyl alcohol) (evoh) as a novel biocompatible polymeric scaffold was surface modified by succinylation to get evohs and further pegylated to improve structural properties using methoxypolyethylene glycol (5000 da) succinate (pegs) along with targeting with retinoic acid (ra) to get final modified active and passive targeted conjugate (pegs-evohs-ra) to evaluate ...
In recent decades, the incidence of cancer has increased significantly, which proves to be a great threaten human life, and brings heavy burden pain individuals, families, society. With cross-fusion traditional medical imaging targeting technology, molecular been expected help non-invasive quantitative observation cell occurrence, development metastasis at cellular level, is conducive grasp act...
The unique advantages and the exciting application prospects of AIEgens have triggered booming developments in this area recent years. Among them, stimuli-responsive received particular attention impressive progress, they been demonstrated to show tremendous potential many fields from physical chemistry materials science biology medicine. Here, achievements terms seven most representative types...
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