Endocytosis, exocytosis, and lateral diffusion are key mechanisms for AMPA receptor trafficking. Endocytosis of AMPARs and other postsynaptic proteins has been proposed to occur at specific endocytic zones (EZs), but the mechanisms that regulate this process are not at all clear. In this issue of Neuron, Lu et al. show that correct synaptic EZ positioning requires links between the GTPase dynam...

This paper highlights the importance of design expertise, for designing liquid retaining structures, including subjective judgments and professional experience. Design of liquid retaining structures has special features different from the others. Being more vulnerable to corrosion problem, they have stringent requirements against serviceability limit state of crack. It is the premise of the stu...

An effort is made to evaluate the formulation of seismic active earth pressure behind a nonvertical retaining wall supporting c-Ф backfill. The formulation is prepared to get a single critical wedge surface for simultaneous action of weight, surcharge, cohesion and adhesion. The success of any retaining structure involves the awareness of seismic active earth pressure. The effect of various par...