The use of 5α-reductase inhibitors (5α-RIs) as prostate cancer chemoprevention agents is controversial. Two large randomized trials, the Prostate Cancer Prevention Trial (PCPT) and the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Trial, have both shown a decreased incidence of prostate cancer in patients administered with 5α-RIs. Both studies showed, however, an increased risk of...

OBJECTIVES Understanding the preferences of patients with multiple sclerosis (MS) for disease-modifying drugs and involving these patients in clinical decision making can improve the concordance between medical decisions and patient values and may, subsequently, improve adherence to disease-modifying drugs. This study aims first to identify which characteristics-or attributes-of disease-modifyi...

provided the original work is properly cited. CC Hypothermia is frequently encountered during major operations despite many efforts to prevent this complication. Numerous reports have identified the adverse effects of hypo thermia including coagulopathy, acidosis, alterations in response to pharmacological agents, detrimental cardiac arrhythmias, and a mortality rate of near 100% for cases with...

The restorative integral support (RIS) model is a whole person response that assists people to overcome adversity. The adverse childhood experiences (ACE) Study conducted by Kaiser Permanente and the Centers for Disease Control and Prevention shows the association between stressors in childhood and multiple later-life health and social problems. Older adults experiencing co-occurring disorders ...

Diagnostic reports. A radiologist at a PACS workstation needs ready access to prior reports. In most situations, reports are initially pushed to the RIS by the SR application, usually via an HL7 interface. If prior reports are stored in the RIS, how can they be available when a radiologist needs to look at them, for example, when reviewing a follow-up exam? T Most RIS systems cannot be queried ...

The NRC is issuing this regulatory issue summary (RIS) to inform recipients of the status of the agency’s efforts to implement the requirements of Section 651(e) of the Energy Policy Act of 2005 (EPAct) on “Treatment of Accelerator-Produced and Other Radioactive Material as Byproduct Material.” This RIS updates the information contained in RIS 2007-22, “Status Update for Implementation of NRC R...

Cases Case 1: A 20-year-old woman suffering a suspected overdose was transported to the hospital. She presented bradycardia with wide QRS waves and QT prolongation, followed by cardiac arrest. Extracorporeal cardiopulmonary resuscitation was implemented, improving circulation. Risperidone and 9OH-RIS levels were 9.6 ng/mL and 127.6 ng/mL, respectively. Case 2: A 54-year-old woman was hospitaliz...

Purpose: Patients with AD commonly exhibit behavioral and psychological symptoms of dementia (BPSD). This study is aimed to compare the efficacy of yokukansan (YKS) and risperidone (RIS) on BPSD in patients with severe Alzheimer’s disease (AD). Methods: Thirty-eight inpatients with AD were investigated. Patients were randomly assigned to the YKS group (N = 18) or the RIS group (N = 20) and trea...

This study extends the work of Kaernbach and Demany @J. Acoust. Soc. Am. 104, 2998–2306 ~1998!# in which regular interval stimuli ~RIS! click trains with first-order intervals could be discriminated from random-interval click trains, but RIS with second-order intervals could not. Kaernbach and Demany concluded that their results cast doubt on autocorrelation as a method of analysis for such sti...

Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that express GABA. However, little is known about how sleep neuron function is determined and how sleep neurons change physiology and behavior systemically. Here, we investigated sleep in Caenorhabditis elegans, which is induced by the single sleep-active neuron RIS. We found that the transcription factor LI...