As the third gasotransmitter, hydrogen sulfide (H2S) plays a crucial role in the physiology and pathophysiology of many systems in the body, such as the nervous, cardiovascular, respiratory, and gastrointestinal systems. The mechanisms for its effects, including inhibiting ischemic injury, reducing oxidative stress damage, regulating apoptosis, and reducing the inflammation reaction in differen...

Ophthalmic diseases are a significant health concern globally, causing visual impairment and blindness in millions of people, particularly dispersed populations. Among these diseases, retinal fundus leading cause irreversible vision loss, early diagnosis treatment can prevent this outcome. Retinal scans have become an indispensable tool for doctors to diagnose multiple ocular simultaneously. In...

distribution of retinal blood vessels (rbvs) in retinal images has an important role in the prevention, diagnosis, monitoring and treatment of diseases, such as diabetes, high blood pressure, or heart disease. therefore, detection of the exact location of rbvs is very important for ophthalmologists. one of the frequently used techniques for extraction of these vessels is region growing-based se...

A number of systemic disorders are attended by distinct changes in blood vessels. The retinal vessels can easily be inspected with an ophthalmoscope. Some changes in retinal vessels allow us to draw direct conclusions about the status of blood vessels in the entire body. Major systemic diseases, such as diabetes or hypertension, can lead to typical changes in the retinal vessels with the result...

BACKGROUND AND PURPOSE Patients with ischemic stroke have a high prevalence of hypertension and diabetes, which are major risk factors for potentially blinding retinal diseases. We studied the prevalence of retinal diseases, and the need for an ophthalmology referral, among persons with acute ischemic stroke. METHODS We conducted a prospective study of 300 consecutive patients with acute isch...

Irreversible vision loss is a worldwide threat. Developing computer-aided diagnosis system to detect retinal fundus diseases extremely useful and serviceable ophthalmologists. Early detection, diagnosis, correct treatment could save the eye’s vision. Nevertheless, an eye may be afflicted with several if proper care not taken. A single image might linked one or more diseases. Age-related macular...

Background: Inherited retinal diseases (IRDs) are a group of genetic disorders with high degrees of clinical, genetic and allelic heterogeneity. IRDs generally show progressive retinal cell death resulting in gradual vision loss. IRDs constitute a broad spectrum of disorders including retinitis pigmentosa and Leber congenital amaurosis. In this study, we performed genotyping studies to identify...