نتایج جستجو برای: retinoic acid

تعداد نتایج: 747591  

2012
Sara E Manoli Lacey A Smith Carrie A Vyhlidal Chang Hyeok An Yolanda Porrata Wellington V Cardoso Rebecca M Baron Kathleen J Haley

BACKGROUND Maternal smoking is a risk factor for pediatric lung disease, including asthma. Animal models suggest that maternal smoking causes defective alveolarization in the offspring. Retinoic acid signaling modulates both lung development and postnatal immune function. Thus, abnormalities in this pathway could mediate maternal smoking effects. We tested whether maternal smoking disrupts reti...

Journal: :Journal of the National Cancer Institute 1998
W Shao M Fanelli F F Ferrara R Riccioni A Rosenauer K Davison W W Lamph S Waxman P G Pelicci F Lo Coco G Avvisati U Testa C Peschle C Gambacorti-Passerini C Nervi W H Miller

BACKGROUND Retinoids, which are derivatives of vitamin A, induce differentiation of acute promyelocytic leukemia (APL) cells in vitro and in patients. However, APL cells develop resistance to retinoic acid treatment. Arsenic trioxide (As2O3) can induce clinical remission in patients with APL, including those who have relapsed after retinoic acid treatment, by inducing apoptosis (programmed cell...

Journal: :International Journal of Applied and Basic Medical Research 2017

Journal: :cell journal 0

introduction: the objective of this study was to evaluated effect of retinoic acid (ra) on the tibia osteogenesis in the chick embryos. materials and methods: for this purpose 0.75mg ra dissolved in 2ml dimthylsulfoxide (dmso) was droped on the limb bud of chick embryos at sixth day of incubation. the osteogenesis of tibia in ra-treated embryos were compared with normal control and dmso-treated...

ژورنال: Anatomical Sciences Journal 2007
Bahar Vand, Hosein, Eftekhari Yazdi, Poopak, Imani, Hosein, Kazemi Ashtiani, Saeed, Parivar, Kazem, Reza Zadeh, Mojtaba, Shahverdi, Abdolhosein, Tahaei, Leyla Sadat,

Purpose: The purpose of this study was to develop an appropriate medium for in vitro maturation (IVM) of immature mouse oocytes. Materials and Methods: Germinal vesicle of female NMRI mouse oocytes (6-8 weeks old) were collected from ovaries and cultured in maturation medium MEM-a, supplemented with: 100 mlIU/ml rFSH+7.5 IU/ml hCG+5% FCS (Control group) and 2mM all- trans retinoic acid (t-RA) ...

Journal: :Journal of cell science 1989
M Edward R M MacKie

The effect of all-trans retinoic acid on metastatic B16 melanoma lung colonization and synthesis and properties of glycosaminoglycans was examined. Injection of tumour cells, pretreated with 10(-6) M-retinoic acid or grown to low density, into the tail vein of syngeneic C57 mice produced significantly fewer pulmonary tumours compared to subconfluent control cells. By cochromatography of glycosa...

Journal: :Cancer research 1985
F H Valone D G Payan

The capacity of retinoic acid to modulate human T-lymphocyte and B-lymphocyte activation by mitogens was examined. T-lymphocyte proliferation stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) or phytohemagglutinin was enhanced by 5 nM to 5 microM retinoic acid in a dose-dependent manner with a 65 +/- 35% (SD) increase (n = 6, P less than 0.01) in TPA-stimulated proliferation induced by 5...

2011
Yuen Fei Wong Jeffrey B. Kopp Catherine Roberts Peter J. Scambler Yoshifusa Abe Alexandra C. Rankin Neelanjana Dutt Bruce M. Hendry Qihe Xu

BACKGROUND Retinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors. Although the location, concentration and roles of endogenous retinoic acid in post-natal kidneys are poorly defined, there is accumulating evidence linking post-natal vitamin A deficiency to impaired renal concentrating and acidifying ...

Journal: :Cancer research 1997
M Isogai M V Chiantore M Haque G Scita L M De Luca

We have previously reported an unexpected relationship between retinoic acid-induced inhibition of cell growth and the ability of various cell lines to metabolize the retinoid. Here, we report that stable expression of the truncated retinoic acid receptor RAR alpha403, transduced in NIH-3T3 cells by a retroviral vector, rendered the cells resistant to retinoic acid for growth inhibition and red...

Journal: :Cancer research 1990
T H Lin T M Chu

Since retinoids have been suggested to be capable of potentiating immunity, the present study was undertaken to determine the effect, if any, on lymphokine-activated killer (LAK) cell activity by retinoic acid, an active metabolite of vitamin A and a differentiation enhancer. Retinoic acid alone was shown to induce no cytotoxicity generated from nylon wool-treated nonadherent murine (BALB/c) sp...

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