A fraction of the low-density lipoprotein (LDL) internalized by cells via receptormediated endocytosis follows a short-circuit pathway, termed "retro-endocytosis," that results in the rapid exocytosis of ligand. Results from the current study suggest that retro-endocytosis of LDL in human fibrobiasts is caused by resurfacing of endocytotic vesicles that contain both free and receptor-bound liga...

This paper evaluates the different AREMA gradations currently in use for their effects on both ballast void space and load carrying performances using a discrete particle analysis computational technique called Discrete Element Modeling (DEM). The effect of gradation on aggregate assembly volumetric properties was first studied. Full-scale ballast layers with common gradations listed in AREMA s...

Teknik tekstiller son yıllarda kullanımı giderek artan ve estetik özelliklerden daha çok fonksiyonellik özellikleriyle ön plana çıkan özel ürünlerdir. Bu nedenle teknik birçok sektöre hitap edebilen ürünleri yapısında bulundurmaktadır. Retro-reflektif tekstiller, içerisinde yer almakta olup, özellikle iş güvenliği uygulamalarında kullanılmaktadır. çalışmada retro-reflektif hakkında bilgi verilm...

This paper presents a Cohesive Zone Model (CZM) approach for investigating dynamic crack propagation in homogeneous and Functionally Graded Materials (FGMs). The failure criterion is incorporated in the CZM using both a finite cohesive strength and work to fracture in the material description. A novel CZM for FGMs is explored and incorporated into a finite element framework. The material gradat...

Thioamides are the preferred pronucleophiles for direct catalytic asymmetric aldol reactions in the context of soft Lewis acid/hard Brønsted base cooperative catalysis. In-depth investigation of this proton-transfer catalysis, which is virtually in equilibrium, revealed that the prominence of the retro-aldol reaction depended on the substrate combination. The retro-aldol reaction is a serious i...

The brain response to a retro-nasally sensed food odour signals the perception of food and it is suggested to be related to satiation. It is hypothesised that consuming food either in multiple small bite sizes or with a longer durations of oral processing may evoke substantial oral processing per gram consumed and an increase in transit time in the oral cavity. This is expected to result in a h...

Treatment of the diol 6 with KH and 18-C-6 at room temperature gives the cyclopentenone 7 in good yields. Mechanistic analysis reveals that this is the first case of an anionic oxy retro-ene reaction followed by a tandem intramolecular aldol condensation. Reaction: see text.

We developed a visible detection system for antibody-catalyzed retro-aldol-retro-Michael reactions. Aldolase antibody 38C2 catalyzed the reaction of substrate 1 to provide 6-bromo-2-napthol that forms a visible colored azo dye with diazonium salts. This system has potential for the screening of novel catalysts.