JCB • VOLUME 170 • NUMBER 4 • 2005 512 Linking centrosomes and actin entrosomal changes during cell division are relayed to the actin cytoskeleton by the centrosomal protein CP190, report Sasidhar Chodagam, Jordan Raff (Gurdon Institute, Cambridge, UK), and colleagues. Although CP190 binds to microtubules and was the first centrosomal protein identified in flies, researchers have not detected a...

Striking inconsistencies between the results of morphometric and electrophysiologic examinations of the regenerating nerve were observed in a previous study featuring the bridging of a 14 mm gap in the rat sciatic nerve. To shed light on this dichotomy, seven further rats were subjected to permanent sciatic nerve transection and assessed electrophysiologically, histologically and by retrograde ...

Combined retrograde tracing (using fluorescent tracer Fast blue) and double-labelling immunofluorescence were used to study the distribution and immunohistochemical characteristics of neurons projecting to the trapezius muscle in mature male rats (n = 9). As revealed by retrograde tracing, Fast blue-positive (FB+) neurons were located within the ambiguous nucleus and accessory nucleus of the gr...

Parkinsonian symptoms are currently thought to be related to hyperactivity of the subthalamic nucleus (STN). Because the STN is known to receive many inputs including glutamatergic cortical afferent fibers, we sought to determine whether the activity of this pathway is altered after dopaminergic denervation to estimate its contribution to the impairment of STN activity. A precise mapping of the...

Immunohistochemical characteristics of neurones innervating the porcine uterus located in paracervical ganglia were studied with a combination of retrograde fluorescent tracing and immunofluorescence. Retrograde fluorescent tracer Fast Blue (FB) was injected into the uterine horn and uterine cervix. The presence of biologically active substances, tyrosine hydroxylase (TH), neuropeptide Y (NPY),...

The variation of permeability with depth can be probed indirectly by various means, including hydrologic models that use geothermal data as constraints and the progress of metamorphic reactions driven by fluid flow. Geothermal and metamorphic data combine to indicate that mean permeability (k) of tectonically active continental crust decreases with depth (z) according to log k ! )14–3.2 log z, ...

The ventral lateral nucleus of the thalamus (VL) serves as a central integrative center for motor control, receiving inputs from the cerebellum, striatum, and cortex and projecting to the primary motor cortex. We aimed to determine the somatotopy and morphological features of the thalamocortical neurons within mouse VL. Retrograde tracing studies revealed that whisker-related VL neurons were fo...

Whereas large injuries to the brain lead to considerable irreversible functional impairments, smaller strokes or traumatic lesions are often associated with good recovery. This recovery occurs spontaneously, and there is ample evidence from preclinical studies to suggest that adjacent undamaged areas (also known as peri-infarct regions) of the cortex 'take over' control of the disrupted functio...

This study examined projections to combination-sensitive neurons in the medial geniculate body of the mustached bat. These specialized neurons respond to the combination of two temporally and spectrally distinct components of the bat's sonar pulse and echo, encoding target information. Combination-sensitive neurons respond to the bat's sonar fundamental, between 24-31 kHz, in conjunction with a...

Integrated pseudosection modeling and monazite petrochronology of paragneiss from the Kanchenjunga region of northeastern Nepal reveal the presence of cryptic tectonometamorphic discontinuities within the Himalayan metamorphic core. These new data outline a series of thrust-sense structures that juxtapose rocks that generally record a protracted history of early Eocene to latest Oligocene–early...