Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...

OBJECTIVES The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. MATERIALS AND METHODS Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture on...

der process and is strongly influenced by bile secretion, pancreatic exocrine secretion, food intake and gastrointestinal motility4. For this reason, many formulations have been proposed to improve the gastrointestinal absorption of cyclosporine A. In 1996, a cyclosporine A formulation in a microemulsion concentrate, containing a surfactant, lipophilic and hydrophilic solvents and an organic so...

In the present work, levofloxacin based microemulsion was developed and its usefulness as topical drug carrier system for anti bacterial activity was investigated. Microemulsion was prepared by phase titration method using oleic acid as oil phase, tween-60 as surfactant and isopropyl alcohol as co-surfactant. Five different formulations were formulated with various amount of the oil, water and ...

The aim of the present study was to prepare, characterize and in-vitro evaluation of a Winsor-IV type microemulsion based drug delivery system incorporating celecoxib as BCS class–II model drug. Attempts were made to prepare cost effective O/W microemulsion using Tween 80, Glycerol, sunflower oil and water. The existence of microemulsion zone was investigated using phase diagrams. The systems w...

Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the components of the microemulsion. Various surfactants and cosurfactants were screened for their ability to emul...

Polyprenol (GBP) from Ginkgo biloba Leaves (GBL) is an important lipid with many bioactive effects. The effect of GBP on antibacterial properties of five antibiotics belonging to different classes was through analysis of inhibition halos, MIC, and FIC index. And we studied the time-killing curves and Ca(2+) mobilization assay in Staphylococcus aureus cells treated with GBP microemulsion and gen...