Abstract Rickets, a growth plate disorder, is classified into calcipenic and phosphopenic types based on the etiology. Phosphopenic rickets can be further fibroblast factor 23 (FGF23) mediated non-FGF23 mediated. FGF-23 has phosphaturic effect which results in hypophosphatemia and, therefore, accumulation of hypertrophied chondrocytes, leading to rachitic changes bones. One most common causes i...

This study was aimed to determine prevalence of vitamin D deficiency and rickets in children with cholestatic liver diseases. Forty eight children with established cholestatic liver disease who referred to gastrointestinal clinic of Children Medical Center (Tehran, Iran) between April 2010 and March 2011 were enrolled in a cross-sectional study. Laboratory analysis including calcium, phosphate,...

Rickets caused by deficiency of vitamin D has almost disappeared in Great Britain, and for this reason attention is being focused more and more on the group of conditions which in the past has been loosely termed ‘ ‘ resistant ‘ ‘ and ‘ ‘ renal ‘ ‘ rickets. Dent (1952) clarified the confusion that has surrounded the subject. He classified the etiolog ’ of the various rachitic and osteomalacic c...

Definite research for the causative factors in the nutritional disturbance known as rickets was begun by various observations as to its distribution and occurrence. In 1890 T. A. Palm (1) showed by a geographical survey that lack of sunlight seemed to be one of the chief factors in the causation of rickets. This led to the use of the sun bath in the treatment of rachitic children. In 1914 Rolli...

Rud syndrome consists of mental retardation, epilepsy, ictihyosis, dentition and skeleton defect. We report a case of Rud syndrome that have clinical, radiological and biochemical characteristics of rickets. Alteration in epidermal cholestrol metabolism, limited sun exposure or associated defects may explain this condition. All such patients need life – long rickets prophylaxis with vitamin D s...

Adult insects achieve their final form shortly after adult eclosion by the combined effects of specialized behaviors that generate increased blood pressure, which causes cuticular expansion, and hormones, which plasticize and then tan the cuticle. We examined the molecular mechanisms contributing to these processes in Drosophila by analyzing mutants for the rickets gene. These flies fail to ini...

We studied the immune system, especially the chemotactic activity of neutrophils, in ten patients with vitamin D-deficient rickets and compared the results with ten healthy controls of matched age. Among all immune system factors, the chemotactic studies persistantly showed remarkable deficiency in leukocyte mobility, both random motion and migration. When compared with controls, the findi...

Privational infantile rickets is now rare in the UK. Privational vitamin D deficiency remains common in the British Asian population, leading to neonatal, infantile and late rickets in childhood and osteomalacia (adult rickets) in Asian women (Dunnigan et al. 1962; Ford et al. 1972a, 1973; Holmes et al. 1973; Stamp et al. 1980). The prevalence of these manifestations of severe vitamin D deficie...

AIM To describe the characteristics of children with vitamin D deficiency rickets and identify common features and predisposing factors. METHODS A review of the clinical notes of all children less than five years of age with radiological evidence of rickets and serum 25-hydroxyvitamin D levels of less than 10 micrograms/L. Patients were identified by searching all low vitamin D levels perform...

Vitamin D-resistant rickets (VDRR), usually inherited in X-linked dominant manner, is the most common type of rickets in developed countries today. This analysis of 13 patients affected by the disease indicates that dental manifestations occur in a wide spectrum of severity which is determined by several factors including heredity, sex, and medical treatment. The spectrum of severity of dental ...