the objectives of this study were to define the clinical risk factors, microbiological spectrum, and visual outcome of bacterial keratitis at shahid sadoughi hospital (yazd, iran). a crosssectional prospective study, identified 80 cases of microbial keratitis from march 1999 to march 2001. inclusion criteria were presence of corneal stromal infiltrate in slit lamp examination, and microbiologic...

the incidence of microbial keratitis after intacs implantation is extremely low and channel infection has been infrequently reported. we present a 23-year-old woman with keratoconus of both eyes who underwent implantation of two intrastromal corneal ring segments (intacs, keravision, inc., fremont, ca, usa) in the right eye. after 2.5 months, the patient presented with decreased vision, inflamm...

AIMS/BACKGROUND To describe a bilateral, mid peripheral, ring-shaped corneal opacity, not resembling any known corneal degeneration, dystrophy, or other disorder, and occurring without ocular or systemic disease. METHODS Ophthalmic examination, haematological screening, and ultrasound biomicroscopy. RESULTS A 25 year old man showed grey-white, granular opacities in both corneas, with an 8 m...

Background: Stromal-mediated signaling enhances NF-kB pathway activity in chronic lymphocytic leukemia (CLL) B cells, leading to cell survival and chemoresistance. Ubiquitination of IkBamay partially account for constitutive activation of NF-kB. MLN4924 is an investigational agent that inhibits the Nedd8activating enzyme, thereby neutralizing Cullin-RING ubiquitin ligases and preventing degrada...

Radiation-related changes including fibrosis, nuclear enlargement, hyperchromasia and cytoplasmic vacuolization may alter the appearance of normal ovarian tissue and ovarian tumors. We describe radiation-related changes in ovarian stromal neoplasm with mixed features of sclerosing stromal tumor and fibrothecoma. The right ovarian mass was discovered in a 38 year-old woman with past history of i...

To determine the T-cell receptor (TCR) V alpha/V beta gene usage of the human autologous gastric tumor-specific cytotoxic T-lymphocytes (CTLs), we first established two pairs of tumor cell lines, HST2 and SSTW, from the malignant peritoneal effusions of signet ring cell carcinomas and their peripheral blood lymphocyte-derived tumor-specific CD8-positive CTL lines, TcHST2 and TcSSTW. TCR V alpha...