Transient generation of reactive oxygen or nitrogen (ROS/RNS), detected with dihydrodichlorofluoroscein by fluorescence microscopy, occurs within minutes of exposing cells to ionizing radiation. In the 1-10 Gy dose range, the amount of ROS/RNS produced/cell is constant, but the percentage of producing cells increases with dose (20 to 80%). Reversible depolarization of the mitochondrial membrane...

Although many viral and bacterial pathogens cause diarrhea, enterotoxigenic E. coli (ETEC) is one of the most frequently encountered in impoverished regions where it is estimated to kill between 300,000 and 700,000 children and infants annually. Critical ETEC virulence factors include pili which mediate the attachment of the pathogen to receptors in the intestinal lumen. In this study we show t...

Tumor-associated myeloid cells are the major type of inflammatory cells involved in the regulation of antitumor immune responses. One key characteristic of these cells is the generation of reactive oxygen (ROS) and reactive nitrogen species (RNS) in the tumor microenvironment. Recent studies have shown the important role of ROS and RNS, especially peroxynitrite, in immune suppression in cancer....

A b s t r a c t This letter discusses simple techniques for the implementation of fault detection in Residue Number System (RNS) arithmetic modules used in systolic arrays. The technique centres around a recently introduced linear systolic structure[1], and does not require a redundant residue system[2] for the detection process. It is shown that this structure can be used as the detection proc...

NO or its derivatives (reactive nitrogen species: RNS) have three types of actions on mitochondria: 1) reversible inhibition of mitochondrial respiration at cytochrome oxidase by NO, and irreversible inhibition at multiple sites by RNS; 2) stimulation of mitochondrial production of superoxide, hydrogen peroxide, and peroxynitrite by NO; and 3) induction of mitochondrial permeability transition ...

Residue Number System (RNS) is a method for representing an integer as an n-tuple of its residues with respect to a given base. Since RNS has inherent parallelism, it is actively researched to implement fast public-key cryptography using RNS. This paper derives the exact error bound of approximation on the Cox-Rower architecture which was proposed for RNS modular multiplication. This is the tig...

In this paper, the design of a Finite Impulse Response (FIR) filter based on the residue number system (RNS) is presented. We chose to implement it in the (RNS), because the RNS offers high speed and low power dissipation. This architecture is based on the single RNS multiplier-accumulator (MAC) unit. The three moduli set 1 {2 ,2 ,2 1} n n n + − , which avoids 2 1 n + modulus, is used to design...

The paper describes a new RNS modular inversion algorithm based on the extended Euclidean algorithm and the plus-minus trick. In our algorithm, comparisons over large RNS values are replaced by cheap computations modulo 4. Comparisons to an RNS version based on Fermat’s little theorem were carried out. The number of elementary modular operations is significantly reduced: a factor 12 to 26 for m...