protein serine/threonine kinase (ROCK), is one of the central regulatory molecules for cytoskeleton control and cell adhesion process. ROCK also involves in other cell functions such as apoptosis and tumor invasiveness. Rho kinase is thought to play an important role in a variety of cellar functions such as stress fiber formation, focal adhesion formation, cell aggregation, cell morphology, cyt...

In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: a b s t r a c t a r t i c l e i n f o A suite of distinctive freshwater subaerial phosphatic stromatolites is developed clos...

In this work, the effect of rock bolt angle on the shear behavior of Rock Bridges is investigated using the particle flow code in two dimensions (PFC2D) for three different Rock Bridge lengths. Firstly, the calibration of PF2D is performed to reproduce the gypsum sample. Then the numerical models with the dimensions of 100 mm * 100 mm are prepared. The Rock Bridge is created in the middle of th...

No prior research has documented the different types of rock coatings in Yosemite Valley, despite the evident black streaks down Yosemite Falls, the light granitic rock exposed by recent rock falls contrasting with dark rock coatings, and the millions of visitors who have photographed the coated rocks of Yosemite. This paper identifies the types of rock coatings found on Half Dome, in Yosemite ...

Combined with specific engineering examples, the spatial disturbance influence characteristics and laws of surrounding rock stress in staggered roadways are analyzed by numerical simulation. This paper concludes that (1) compared pressure behavior general roadway, stability roadway is relatively poor, showing local serious behavior, such as intensified destruction side, failure fracture penetra...

Introduction: We have completed analysis of a new near-field rock count at the Mars Pathfinder landing site and determined that the previously published [1,2] rock count suggesting 16 % cumulative fractional area (CFA) covered by rocks is incorrect. The earlier value is not so much wrong (our new CFA is 20%), as right for the wrong reason: both the old and the new CFA’s are consistent with remo...

Original scientific paper Rock burst is a common serious geological hazard in underground engineering, which seriously affects the progress of projects. The mechanism of rock burst can be explained by the distribution law of rock fragments and its fractal characteristics. A simulation experiment of rock burst was conducted with the granite samples under a biaxial loading machine system to analy...

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neuritogenesis, to prion diseases. We found that overactivation of ROCK signaling occurred in neuronal s...

1 Department of Endocrinology and Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA, 2 GIM Foundation, Little Rock, AR, USA, 3 Department of Internal Medicine and Hospital Medicine, Christus Trinity Mother Frances Hospital, Tyler, TX, USA, 4 Department of Policy, University of Arkansas for Little Rock, Little Rock, AR, USA, 5 Tutwiler Clinic, Tutwiler, MS, USA...