Peroxisome proliferator-activated receptor-γ (PPARγ) and Rho-kinase (ROCK) regulate smooth muscle cell (SMC) proliferation and contribute to vascular remodeling in adult pulmonary hypertension. Whether these pathways interact to contribute to the development of vascular remodeling in persistent pulmonary hypertension of the newborn (PPHN) remains unknown. We hypothesized that ROCK-PPARγ interac...

methods and principles used in education come from diverse foundations. this paper aims at examining philosophical and psychological foundations of education based on two similar views from the west and the east: the illuminationist philosophy of suhrawardi and phenomenology of husserl. questions of the research deal with philosophical and psychological foundations of education from the standpo...

Batter rock-socketed piles (BRSP) foundation is one of common foundations, such as port engineering or cross-sea bridge, while there are few studies on negative skin friction for BRSP. A series model tests conducted to explore BRSP which embedded in thick soft clay. The effects the inclined angle and soil consolidation time resistance bending moment analyzed. test results show that: development...

Rock physics modeling aims to provide a link between rock properties, such as porosity, lithology, and fluid saturation, and elastic attributes, such as velocities or impedances. These models are then used in quantitative seismic interpretation and reservoir characterization. However, most of the geophysical measurements are uncertain; therefore, rock physics equations must be combined with mat...

Rho-associated kinase (ROCK) I mediates signaling from Rho to the actin cytoskeleton. To investigate the in vivo functions of ROCK-I, we generated ROCK-I-deficient mice. Loss of ROCK-I resulted in failure of eyelid closure and closure of the ventral body wall, which gave rise to the eyes open at birth and omphalocele phenotypes in neonates. Most ROCK-I(-/-) mice died soon after birth as a resul...

27 Using projective and objective measures, effects of rock music on emotion were investigated. Sixty students were randomly assigned to three conditions: hard rock, soft rock, and no music. One group listened to hard rock music while taking a projective test with five ink blots and an objective test with an Emotional Assessment Scale (EAS). The same procedure was used for the second group whil...

The homologous mammalian rho kinases (ROCK I and II) are assumed to be functionally redundant, based largely on kinase construct overexpression. As downstream effectors of Rho GTPases, their major substrates are myosin light chain and myosin phosphatase. Both kinases are implicated in microfilament bundle assembly and smooth muscle contractility. Here, analysis of fibroblast adhesion to fibrone...

The evaluation of local stability of the tunnel surrounding rock mass with weak rock layer is very important for the economy and security of the tunnel construction. Based on the rock tunnel geological conditions in the construction, the finite element model of the tunnel surrounding rock mass stability analysis with weak rock layer is established in the article by selecting the ABAQUS program ...

In terms of target detection and classification, scattering from exposed rock on the seafloor, (i.e., individual rocks and rock outcrops) presents some of the most difficult challenges for modern MCM and ASW sonar systems in shallow water. Work on characterizing, modeling and simulating mean levels and other statistical measures of acoustic scattering from rocks and rock outcrops is therefore c...

After the Law on Foundations was formed, every Foundation that existed before enactment of obliged to adjust its Articles Association with provisions Foundations. If not, there will be legal consequences for foundations have not made adjustments, or in other words, foundation legally weak and also an impact assets/wealth foundation. The purpose this study is find out implications new do comply ...