Previous studies suggest that rodent burrows, a proxy for rodent population are important for predicting plague risk areas. However, studies that link landform, surface attributes and rodent burrows in the Western Usambara Mountains in Tanzania are scanty. Therefore, this study was conducted in plague endemic area of the Western Usambara Mountains in northern, Tanzania, to explore the relations...

BACKGROUND Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused by hantaviruses. Landscape can influence the risk of hantavirus infection for humans, mainly through its effect on rodent community composition and distribution. It is important to understand how landscapes influence population dynamics for different rodent species and the subsequent effect on HFRS risk. ...

Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the field of papillomavirus biology. Two rodent papillomaviruses, MnPV1, which inf...

Abstract: Selecting the most appropriate first-in-human and pharmacologically active dose for any new drugs or biologicals is a crucial step before starting clinical trial investigation in adult healthy human subjects. Extrapolation of between various rodent non-rodent animal species critical biomedical researchers during initial drug development. The objective this review to provide practical ...

Four rodent control techniques-sustained baiting (SB) with cournachlor. pulsed baiting (PB) with brodifacoum. a lethal electrified barrier (LEB), and a nonlethal electrified barrier (NLEB)-were evaluated on the experimental fann of the International Rice Research Institute (IRRI) in the Philippines. A fifth treatment (no experimental rodent control) was established for reference. Mean tiller da...

We conducted a natural removal experiment, utilizing a local outbreak of sylvatic plague (Yersinia pestis) as the removal agent, to test the effects of removal of Gunnison’s prairie dogs (Cynomys gunnisoni) on plant and nocturnal rodent assemblages in three grassland habitats (ponderosa, pinyon-juniper, and desert grasslands) in northern Arizona. We measured plant cover, rodent abundance, plant...

Introduction:  Results: These findings revealed the exaggerated responses in the group which received CCI. The group which was treated by 1 μg/kg of 1,25 vit D3 showed a significant reduction in pain behavior. Injection of 1,25 vit D3 did not change the response of animals to the acetone drop and von frey filament. Discussion: Our results showed that antinoceptive effect of 1,25 vit D3 in a rod...

Polyethylenimine (PEI) has been proposed as a non-viral vector, and has been successfully used to transfer reporter genes into the central nervous system (CNS), kidneys, and lungs of adult mice. Neuropeptide Y (NPY) is a peptide expressed in the hypothalamus and is important in the regulation of body weight. Using PEI combined with stereotactic microinjection, we have successfully transferred c...