We describe a computational protocol, called DDMI, for redesigning scaffold proteins to bind to a specified region on a target protein. The DDMI protocol is implemented within the Rosetta molecular modeling program and uses rigid-body docking, sequence design, and gradient-based minimization of backbone and side-chain torsion angles to design low-energy interfaces between the scaffold and targe...

BACKGROUND A surgical safety checklist (SSC) was implemented and routinely evaluated within our hospital. The purpose of this study was to analyze compliance, knowledge of and satisfaction with the SSC to determine further improvements. METHODS The implementation of the SSC was observed in a pilot unit. After roll-out into each operating theater, compliance with the SSC was routinely measured...

Cellulose nanofibril (CNF) suspensions are not easily coatable because of their excessively high viscosity and yield stress, even at low solids concentrations. In addition, CNF suspensions vary widely in their properties depending on the production process used, which can affect their processability. This work reports roll-to-roll coating of three different types of CNF suspensions with a slot-...

Simplified models relating pitch and roll angle measurements of a roving vehicle to terrain slope and vehicle attitude were developed. The simplified models are based on previously published models by Rowe and Spencer [1] and Yang et al. [2]. These simplified models are easier to implement using microcontroller technology reducing the number of trigonometric function calculations, improving pro...

Amongst the ever-growing toolbox of microand nanofabrication techniques, polymer replication-based processes continue to attract attention due to the conceptual simplicity, reproducibility, and great variety of often cheap materials that can be used. Cost and time saving advantages are further provided by high throughput replication techniques such as roll-to-roll nanoimprint lithography [ 1 ]

Organic thin-film transistors (TFTs) are of interest for a variety of large-area electronics applications, such as flexible active-matrix displays and conformable sensor arrays [1]. Among the challenges in the development of high-performance organic TFTs, especially on flexible polymeric substrates, is to realize organic TFTs that simultaneously provide a large field-effect mobility, a large on...

Roll-to-roll (R2R) slot-die coating systems are mostly devoted to the mass manufacture of printed electronics. This study examined the correlation among the operating conditions, thickness, and width of the patterned strip fabricated by the R2R slot-die system. A full factorial experiment was conducted to screen for effective parameters. The velocity of a moving substrate was found to be the mo...

The following approach of a fluidic based self-assembly process uses the surface forces for a precise handling and positioning of small devices for a roll-to-roll manufacturing. The surface, on which the device should be positioned, will be functionalized with hydrophile and hydrophobic areas. Thus water droplets can be caught on the hydrophile areas. The devices to be positioned will be placed...

Technologies based on organic semiconductors may answer the increasing demands that consumers make in the areas of large-area electronics, lightweight displays, and portable computing. Advances in scientific understanding, technology, and device performance have occurred particularly rapidly in the area of polymer light-emitting diodes (LEDs). Material properties and economic considerations sug...