Leukocytes roll along the endothelium of postcapillary venules in response to inflammatory signals. Rolling under the hydrodynamic drag forces of blood flow is mediated by the interaction between selectins and their ligands across the leukocyte and endothelial cell surfaces. Here we present force-spectroscopy experiments on single complexes of P-selectin and P-selectin glycoprotein ligand-1 by ...

A precise prediction of the rolling force is critical to ensure quality final product, especially in cold thin strips. Based on this, a new mathematical model developed work out when considering roll crossing angle and shifting values at speed ratios 1.1, 1.2 1.3. An iterative method was used indicate contact area shape, from which automatically calculated using Matlab™ code for cases cross ang...

* Corresponding author. Tel.: +1-612-625-2374; fax: +1-612-626-7750. E-mail addresses: [email protected] (A. Drescher), [email protected] (J.P.Hambleton). 1 On modeling a rolling wheel in the presence of plastic deformation as a threeor two-dimensional process J.P. Hambleton and A. Drescher Department of Civil Engineering, University of Minnesota, 500 Pillsbury Drive SE, Minneapolis, MN 55455, US...

Based on the stochastic rolling force data from aluminum hot strip tandem mill, the ARMA time series model and the stochastic excitation power spectral density (PSD) model are established, and the stochastic rolling forces excitation model is established by utilizing Levenberg-Marquardt combined with generalized global planning algorithm. A two dimensional stochastic nonlinear dynamical model o...

Two continuously variable transmissions are examined, one that relates a pair of linear speeds and another that relates a pair of angular speeds. These devices are elemental in the design of cobots, a new class of robot that creates virtual guiding surfaces to aid a human operator in assembly tasks. Both of these transmissions are traction drive mechanisms that rely on the support of either lat...

This study aimed to analyse the kinematic, kinetic and electromyographic characteristics of four front crawl flip turn technique variants. The variants distinguished from each other by differences in body position (i.e., dorsal, lateral, ventral) during rolling, wall support, pushing and gliding phases. Seventeen highly trained swimmers (17.9 ± 3.2 years old) participated in interventional sess...

Mechanical properties of neutrophils have been recognized as key contributors to stabilizing neutrophil rolling on the endothelium during the inflammatory response. In particular, accumulating evidence suggests that surface protrusion and tether extraction from neutrophils facilitate stable rolling by relieving the disruptive forces on adhesive bonds. Using a customized optical trap setup, we a...

The selectin family of leukocyte adhesion receptors is principally recognized for mediating transient rolling interactions during the inflammatory response. Recent studies using ultrasensitive force probes to characterize the force-lifetime relationship between P- and L-selectin and their endogenous ligands have underscored the ability of increasing levels of force to initially extend the lifet...

Wall shear stress in postcapillary venules varies widely within and between tissues and in response to inflammation and exercise. However, the speed at which leukocytes roll in vivo has been shown to be almost constant within a wide range of wall shear stress, i.e., force on the cell. Similarly, rolling velocities on purified selectins and their ligands in vitro tend to plateau. This may be imp...