introduction rosacea is a chronic skin disease affecting the facial area. the causative agents are unknown. demodex mites can cause rosacea in human beings. case presentation in this article five cases of rosacea due to demodex folliculorum are reported. the first case was a 26-year-old male wrestler. the second case was a 4-year-old-boy with immunodeficiency syndrome, the third case was a 29-y...

background and objective: rosacea is a common and ill-defined disease and demodex folliculorum has been reported in rosacea in a number of clinical studies. since demodex mite is present in many healthy individuals, the mite may have a pathogenic role only when it is present in high densities. therefore, in this study, the possible role of demodex folliculorum and the importance of mite density...

Rosacea is a chronic facial skin condition of unknown cause. It is characterized by marked involvement of the central face with transient or persistent erythema, telangiectasia, inflammatory papules and pustules, or hyperplasia of the connective tissue. Transient erythema, or flushing, is often accompanied by a feeling of warmth. It usually lasts for less than five minutes and may spread to the...

PURPOSE To investigate correlation between ocular Demodex infestation and serum. DESIGN A prospective study to correlate clinical findings with laboratory data. PARTICIPANTS We consecutively enrolled 59 patients: 34 men and 25 women with a mean age of 60.4+/-17.6 years (range, 17-93). METHODS Demodex counting was performed based on lash sampling. Serum immunoreactivity to two 62-kDa and 8...

Health-related quality of life (HRQoL) of rosacea patients is a relevant outcome measure in research and clinical practice. A review of the literature was systematically carried out regarding levels of HRQoL of patients with rosacea, including associations between HRQoL scores, demographic and clinical characteristics. Searches were performed in Cochrane, PubMed, EMBASE, PsycINFO, CINAHL and LI...

Although it is debatable whether Helicobacter pylori may play a role in the pathogenesis of rosacea, some authors suggested that the treatment of H. pylori might have a beneficial effect. The aim of this investigation was to compare the prevalence of H. pylori between rosacea patients and controls, and to evaluate an effect of H. pylori eradication on rosecea by a 2-week triple therapy that was...

Rosacea is a chronic inflammatory skin disease whose pathophysiological mechanism is still unclear. However, it is known that mast cell (MC) numbers are increased in the dermis of rosacea patients. MC proteases not only recruit other immune cells, which amplify the inflammatory response, but also cause vasodilation and angiogenesis. MCs are also one of the primary sources of cathelicidin LL-37 ...

Increased expression of cathelicidin antimicrobial peptide (CAMP) is related to the pathogenesis of rosacea. CAMP plays a crucial role in antimicrobial defences, such as the killing of mycobacteria. CAMP gene expression is regulated by vitamin D-dependent (VDR) and vitamin D-independent (C/EBPα) transcription factors. VDR-dependent CAMP expression is sufficient during the summer months in Nordi...

BACKGROUND Rosacea, a common chronic skin disorder, is currently managed by patient education, pharmacological drugs, medical devices (laser and light therapies), and use of proper skin cares. Unfortunately, none of these actual treatments used alone or in combination is curative, and so we proposed a dermocosmetic active ingredient to mitigate some aspects of the rosacea and particularly for e...