INTRODUCTION In the settings of trauma, liver transplantation and major surgery multifactorial coagulopathies are frequently encountered. The treatment of acutely bleeding patients is critically compromised by monitoring with standard available routine coagulation tests. In contrast to conventional tests, rotational thromboelastometry (ROTEM) provides an automated measurement of interactive dyn...

INTRODUCTION Today, the pneumatic tube transport system (PTS) is used frequently because of its advantages related to timing and speed. However, the impact of various types of PTS on blood components is unknown. The aim of this study was to examine the influence of PTS on the quality of routine blood cell counts, erythrocyte sedimentation, and certain blood coagulation tests. MATERIALS AND ME...

A new method for the specific assay of prothrombin is described which utilises Taipan snake venom and the chromogenic substrate Tos-Gly-Pro-Arg-pNA (Chromozym TH). The method is sensitive and reproducible and shows good correlation with a conventional specific assay for prothrombin. The reaction is dependent on calcium ions and phospholipid, and is therefore sensitive to the coumarin-induced pr...

Abstract In Coronavirus disease 2019 (COVID-19) subjects, recent evidence suggests the presence of unique coagulation abnormalities. this study, we performed clot waveform analyses to investigate whether specific modulations are observed in COVID-19 subjects. We analyzed second derivative absorbance routine APTT tests using an ACL-TOP system. high frequencies abnormal patterns second-derivative...

The importance of vitamin K to coagulation is well known but there is increasing evidence that vitamin K has a diverse role in the body including the maintenance of bone health, preventing inappropriate calcification in soft tissues, and a protective role in inflammation. There is evidence that most, if not all, of these non-coagulation functions require higher dietary intakes than those requir...

History of Present Illness: The patient had relocated to the United States from the Philippines 10 months previously. She had seen a fertility specialist 10 days previously to determine her suitability as a gamete donor. As part of the physical examination, routine bloodwork was performed, including a metabolic profile, complete blood count (CBC), and coagulation screening tests (prothrombin ti...

Editor—We read with interest the editorial proposing that the routine measurement of a patient’s coagulation status should be abandoned in the absence of a family or personal history, an acute illness, or anticoagulation therapy. The authors are correct that questioning the patient about clotting abnormalities and bleeding disorders should form an essential part of the pre-anaesthetic medical a...