Using rats of the Lewis and BN (Ag-B locus incompatible) isogenic strains, a comparative study has been made of the capacity to prevent or mitigate the development of runt disease with: (a) lymph node cell suspensions from normal adult BN rats, (b) node cells, or (c) serum from donors sensitized against Lewis tissue antigens, or (d) heterologous anti-lymphocyte serum (ALS) raised in rabbits aga...

The ability of parental to F(1) spleen grafts to regenerate was equal to that of parental to parental or to F(1) or F(1) spleen grafts. Cytotoxicity analysis of parental to F(1) spleen and thymic grafts indicated that these "regenerated grafts" were composed of F(1) lymphocytes. Regenerated parental to F(1) spleen grafts were incapable of producing runt disease in newborn F(1) animals.

This work aimed to investigate the effect of Sophora flavescens polysaccharide on proliferation and osteogenic differentiation dental pulp stem cells. The cells were isolated from rat crown tissue surface biomarkers identified by flow cytometry. was assessed alizarin red staining alkaline phosphatase staining. treated with different doses for time points cell viability counting kit 8. Cell migr...

This supplementary document concerns the cross-regulatory interactions between the five primary pair-rule genes (hairy, eve, runt, ftz, and odd) during cellularisation. Looking at each gene in turn, I examine the evidence for its expression being directly regulated by the other primary pair-rule factors. The conclusions form the basis for the topology of the “early” pairrule network presented i...

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational le...

We present runt pruning, a new clustering method that attempts to find modes of a density by analyzing the minimal spanning tree of a sample. The method exploits the connection between the minimal spanning tree and nearest neighbor density estimation. It does not rely on assumptions about the specific form of the data density (e.g., normal mixture) or about the geometric shapes of the clusters,...