The basis for our score is a feature vector corresponding to a given input. In our case, the input is a sequence to be classified, and the features are going to be the output of certain tools (see workflow in Figure 1) we feed with the input sequence. In the following, we describe the two distinct steps necessary for the computation: as a prerequisite, we first establish distributions from our ...

Table B: One-tailed p-values for F̂ST based on WGS data. †With the exception of the compairison between MKK and MLA in 2014, all p-values are Monte Carlo estimates based on 1000 random permutations as described in Table A. The p-value for MKK and MLA in 2014 is exact, since there were fewer than 1000 possible permutations given nMKK = 4 parasite samples from MKK, and nMLA = 8 parasite samples fr...

n k − is the rate of constitutive degradation of lateral signaling. Lateral signaling is mediated by complexes of LIN-12-cyto with LAG-1 transcription factor. Silencing of lateral signaling occurs due to proteosomal degradation of LIN-12-cyto [1]. The mean half-life of proteins susceptible to proteolysis has been measured to be approximately 43 minutes [2]. Therefore, the reference value of par...

Deger C1, Ozdemir O2, Eldem B3, Unlu N4, Alp MN5, Saatci AO6, Ozmert E7, Altintas KA8, Sermet F7, Erdal E1, Sar C1, Asan S1, Sumer F1, Parali E1, Ozel O1 1 Bayer Turk Kimya San. Ltd. Sti., Istanbul, Turkey, 2 Yorum Consultancy Ltd., Istanbul, Turkey, 3 Hacettepe University Faculty of Medicine, Ankara, Turkey, 4 Ankara Training & Research Hospital, Ankara, Turkey, 5 Ankara Numune Training & Rese...

Reduction of virginiamycin S with sodium borohydride produces allo- and normal-dihydro-virginiamycin S. Reduction of the tosylhydrazone of virginiamycin S with sodium cyanoborohydride affords deoxyvirginiamycin S. These compounds are less active than virginiamycin S. Like virginiamycin S they enhance the activity of virginiamycin M1.