BACKGROUND Depression and anxiety are prevalent serious psychiatric disorders. Several drugs are used to treat these conditions but these are often associated with serious side effects. For this reason alternative therapies, including herbal medication such as saffron, have been proposed. We aimed to assess the effects of saffron extract for the treatment of anxiety and depression using a 12-we...

OBJECTIVES Saffron is the stigma of Crocus sativus L., which has the potentials to play a role in the treatment of many diseases. Although many researches are now going on this precious spice, there are few data on saffron safety in human, especially in patients with chronic mental illnesses. This study aimed to evaluate the short-term safety and tolerability of both saffron and crocin (its maj...

To inquire about the possibility of durable valorization saffron, this review highlights different techniques in vitro culture and varietal creation specie. Then, a reveal main component saffron with some pharmacological activities that make product serious therapeutic hope. Saffron (Crocus sativus L.) is sterile triploid geophyte propagated by corms. respond to increasing global demand for it ...

background: obesity is pandemic worldwide and a strong risk factor for cardio-metabolic disorders. the few approved anti-obesity drugs have poor efficacy and safety profile. thus, there is an urgent need for new anti-obesity agents. according to the traditional medicine and a clinical trial, saffron may have anorexigenic and anti-obesity effects which need further investigation. objectives: eva...

background: recent studies have indicated potential of saffron for applying in a wide variety of diseases such as psychiatric and neurologic disorders. the concurrent use of saffron with ssris can lead to reducing the dose of ssris. saffron at a dose of 200 mg may change some hematological and biochemical parameters. objective: the goal of this trial was to assess the safety of concomitant admi...

background: there is much debate about effects of medicinal plants such as saffron (crocus sativus) on human health. women are highly involved in farming and processing of this plant. this study is aimed at evaluating the saffron impacts on miscarriage rate of female farmers working in saffron fields. methods: this was a prospective case-control study on pregnant female farmers during harvestin...

islamic traditional medicine (itm) is a holistic system of medicine. saffron (crocus sativus) is one of the most famous plants cultivated in iran and has a wide range of activities such as oxytocic, anti-carcinogenic, exhilarant, anti-depressant, and anti-asthma effects. in addition, saffron can increase the bioavailability and enhance absorption of other drugs. this study comprises a bibliogra...

current therapies for breast cancer are often limited by short-term efficacy due to the emergence of drug resistance. there has been increased interest in the use of naturally occurring compounds with chemopreventive and chemotherapeutic effects in the treatment of cancers. saffron, dry stigmas crocus sativus l., used in iran as a spice, is known for its anticancer properties. in this study, th...