Cerebral ischemia produces brain damage and related behavioral deficits such as memory. In this study, a rat model of chronic cerebral hypoperfusion was used to determine whether saffron extract and crocin, which are potent antioxidants and free radical scavengers, can reduce vascular cognitive impairment. Male adult Wistar rats were administered different doses of an aqueous solution of crocin...

Saffron, obtained from the dried stigmas of Crocus sativus L., is an important spice, rich in carotenoids. Carotenoids are capable of protecting cells from the attack of free radicals, which naturally develop during sunbathing, smoking, exercise – even breathing oxygen. It has been estimated that our body needs 6 to 30 mg of carotenoids per day to protect its cells. These amounts are normally c...

Saffron (Crocus sativus Linn.) has been an important subject of research in the past two decades because of its various biological properties, including anti-cancer, anti-inflammatory, and anti-atherosclerotic activities. On the other hand, the molecular bases of its actions have been scarcely understood. Here, we elucidated the mechanism of the hypoglycemic actions of saffron through investiga...

OBJECTIVE The aim of this double-blind and placebo-controlled trial was to investigate whether saffron (stigma of Crocus sativus L.) could relieve symptoms of premenstrual syndrome (PMS). DESIGN Double-blind, randomised and placebo-controlled trial. SETTING Departments of Gynaecology/Obstetrics and Psychiatry, Tehran and Zanjan University of Medical Sciences. POPULATION Women aged 20-45 y...

The aim of this study was to synthesize chemically activated carbons from different agricultural residues, i.e., pistachio shell (PS), bitter orange peel (OP), and saffron petal (SP), subsequently use them as supports for loading a Ni catalyst. Supercritical water gasification bio-oil applied investigate the catalytic performance resulting catalysts. physicochemical properties carbon (ACs) cata...

Lung cancer is the leading cause of cancer-related death worldwide. Here we investigated the antitumor effect and mechanism of Zhejiang (Huzhou and Jiande) saffron against lung cancer cell lines, A549 and H446. Using high performance liquid chromatography (HPLC), the contents of crocin I and II were determined. In vitro, MTT assay and annexin-V FITC/PI staining showed cell proliferation activit...

Aquaporins are water channel proteins that facilitate the passage of water through biological membranes and play a crucial role in plant growth. We showed that ethylene treatment significantly reduced petal size, inhibited expansion of petal abaxial subepidermal cells, and decreased petal water content in rose (Rosa hybrida 'Samantha'). Here, we report the isolation of a plasma membrane aquapor...

PURPOSE The present study sought to investigate whether Crocus sativus stigmas (saffron) extract prevents selenium-induced cataractogenesis in vivo, and to study its possible protective mechanism. METHODS Wistar rat pups were randomized into three groups. Group I (control) received subcutaneous injection of normal saline on postnatal day 10. Groups II (selenite-treated) and III (selenite+saff...

Saffron (Crocus sativus L.) is one of the most important and expensive medicinal spice products in the world. Because of its high market value and premium price, saffron is often adulterated through the incorporation of other materials, such as Carthamus tinctorius L. and Calendula officinalis L. flowers, Hemerocallis L. petals, Daucus carota L. fleshy root, Curcuma longa L. rhizomes, Zea may L...

Saffron is an important crop in social and economical aspects in Khorassan Province (Northeast of Iran). In this research we tried to evaluate trends of saffron yield in recent years and to study the relationship between saffron yield and the climate change. A regression analysis was used to predict saffron yield based on 20 years of yield data in Birjand, Ghaen and Ferdows cities. Climatologic...