Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects ca...

The quantitative analysis of salicylate provides useful information for the evaluation of metabolic processes in plants. We report a simple, noninvasive method to measure salicylate in situ in Ocimum basilicum leaves using reverse iontophoresis in combination with cyclic voltammetry at disposable screen-printed electrodes and the concentration of salicylate in basil leaves was found to be 3 mM.

Introduction: The prostaglandin E2 (PGE2), a cyclooxygenase (COX) product, play critical roles in the synaptic plasticity. Therefore, long term use of COX inhibitors may impair the synaptic plasticity. Considering the wide clinical administration of aspirin and its unknown effects on information processing in the brain, the effect of aspirin and sodium salicylate on the short term synaptic p...

1. The renal clearance of salicylate has been measured in two groups of patients undergoing treatment by alkaline diuresis for salicylate poisoning. One group received mannitol and sodium lactate, the other acetazolamide and sodium bicarbonate. 2. The relationship between urine pH and salicylate clearance was found to be the same in both groups and similar to that shown at non-toxic concentrati...

Bezoar formation is cited to be the cause of delayed absorption of aspirin in overdose of enteric-coated aspirin preparation. However, such phenomenon from oral overdose of regular aspirin preparation has not been clearly demonstrated in human. The use of multiple-dose activated charcoal (MDAC) in salicylate poisoning remains controversial. We report a case of regular-preparation salicylate poi...

The effect of salicylate on the metabolism of peripheral blood lymphocytes in tissue culture was investigated. Lymphocytes incubated with sodium salicylate at a concentration of 30 mg/100 ml showed increased glucose consumption, lactic acid production, and oxygen consumption, evidence for uncoupling of oxidative phosphorylation. No decrease in cell number or viability (trypan blue dye exclusion...

were fundamentally different from those evoked by a real sound, we proposed that tinnitus originates in the brain. To identify potential drugs to treat tinnitus, we developed rat behavioral models of tinnitus. Like humans, rats exposed to high intensity noise developed tinnitus; in some cases, the tinnitus was transient while in others it was persistent. Humans develop tinnitus after taking hig...

Salicylate, one of the most widely used drugs, produces at repetitive high doses reversible tinnitus and hearing loss. Neural correlates of hearing loss have long been established, whereas they remain elusive for tinnitus. The average spectrum of electrophysiological cochleoneural activity (ASECA), a measure of spontaneous auditory nerve activity, was monitored in guinea pigs over weeks of sali...

Previous investigations in this Laboratory (Hetzel, Charnock & Lander, 1959; Charnock, Lockett & Hetzel, 1962) have shown that the administration of therapeutic doses of salicylate drugs to both man and rats disturbs the normal electrolyte balance in addition to increasing the metabolic rate. The chronic administration of both sodium salicylate and potassium salicylate to rats produces a signif...