The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus. It has also been shown to be a potential biomarker for breast, ovarian and testicular cancer. Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland. The aim of this study was to determine whether hK...

The standard of care for head and neck cancer typically includes surgical resection of the tumor followed by targeted head and neck radiation. However depending on tumor location and stage, some cases may not require surgical resection while others may be treated with chemoradiation. Unfortunately, these radiation treatments cause chronic negative side effects for patients. These side effects a...

Major salivary gland tumors are very rare in the developmental period. Confirming tumor changes of the salivary gland requires precise diagnostic imaging involving an ultrasonography scan, computed tomography and magnetic resonance. A needle aspiration biopsy (NAB) of a tumor is of high importance. Excision of the tumor is the main treatment method in the case of parotid gland tumors. Statistic...

hyalinizying clear cell carcinoma is a rare tumor which affects women more than men and is more common in minor salivary glands. the purpose of this paper was to describe a case of hyalinizing clear cell carcinoma of buccal vestibule in a 55-year-old woman. it is important to differentiate this neoplasm from other tumors with clear cell features because of their differences in treatment and cli...

Estrogen receptors (ERs) expression has been studied in salivary gland tumors, however, there are conflicting results regarding its expression in the literatures. The aim of this study was to investigate the expression of estrogen receptors protein (ERs) in pleomorphic adenoma (PA) and mucoepidermoid carcinoma (MEC) of salivary glands using immunohistochemistry. 35 cases of intraoral minor sali...

OBJECTIVES This study aims to evaluate our single center experience in patients with a salivary gland tumor receiving postoperative radiation therapy (RT). PATIENTS AND METHODS Between January 1996 and December 2011, the records of 34 salivary gland tumor patients who were operated and referred to our clinic for adjuvant RT were retrospectively analyzed. Radiation therapy was applied to the p...

BACKGROUND Saliva (oral fluids) is an emerging biofluid poised for detection of clinical diseases. Although the rationale for oral diseases applications (e.g. oral cancer) is intuitive, the rationale and relationship between systemic diseases and saliva biomarkers are unclear. METHODOLOGY/PRINCIPAL FINDINGS In this study, we used mouse models of melanoma and non-small cell lung cancer and com...

Salivary gland neoplasms are a diverse group of tumours and appropriate treatment depends on adequate understanding of the pathophysiologic behaviour of each tumour type. Most (95%) salivary glands occur in adults. Benign tumours are slow growing tumours and attain a considerable size before presenting to surgeon. We report a case of huge tumour of left submandibular gland that presented in our...

Salivary gland choriostoma is defined as a tumor-like growth of otherwise normal salivary gland found in an abnormal location. It has been reported in the head and neck regions but there are very few reports of its presence in the gastrointestinal tract [1,2]. To our knowledge, it has been reported in the jejunal [3], sigmoid colon [4], rectal [5,6], and perianal regions [7], but there is no re...