Distant sequence relationships in proteins containing the beta jelly-roll fold were investigated using sensitive sequence comparison methods, including PSI-BLAST and Hidden Markov Models. A relationship was identified between the rmlC-like and phosphomannose isomerase SCOP (version 1.53) superfamilies, which were merged in the most recent SCOP release. No other distant sequence relationships li...

Some sciences are exciting because of their generality and some because of their predictive power. Immunology is particularly exciting, however, because it provokes unusual ideas, some of which are not easily come upon through other fields of study. Indeed, many immunologists believe that for this reason, immunology will have a great impact on other branches of biology and medicine. On an occas...

Susann Schrenk * — Teodor Gabriel Crainic ** — Van-Dat Cung* — Gerd Finke* * G-SCOP, Laboratoire des Sciences pour la Conception, l’Optimisation et la Production , INPG-UJF-CNRS, 46, avenue Félix Viallet, 38031 Grenoble, France. susann.schrenk(van-dat.cung,gerd.finke)@g-scop.grenoble-inp.fr ** Département management et technologie et Centre de recherche interuniversitaire sur les réseaux d’entr...

Bushen‑Yizhi formula (BSYZ), a traditional Chinese medicine formula consisting of six herbs has been reported to possess a neuroprotective effect. The present study aimed to investigate the effects of BSYZ on learning and memory abilities, as well as oxidative stress and neuronal apoptosis in the hippocampus of scopolamine (SCOP)‑induced senescence in mice, in order to reveal whether BSYZ is a ...

MOTIVATION The sequence patterns contained in the available motif and hidden Markov model (HMM) databases are a valuable source of information for protein sequence annotation. For structure prediction and fold recognition purposes, we computed mappings from such pattern databases to the protein domain hierarchy given by the ASTRAL compendium and applied them to the prediction of SCOP classifica...

Guided by a hemostasis bioassay, seven terpene glycosides were isolated from the roots of Sanguisorba officinalis L. by silica gel column chromatography and preparative HPLC. On the grounds of chemical and spectroscopic methods, their structures were identified as citronellol-1-O-α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside (1), geraniol-1-O-α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside (2),...

Sanguisorba officinalis is a natural plant that has been traditionally used for the treatment of inflammatory and metabolic diseases. Several studies have reported that its extracts exhibit anticancer, antioxidative and anti-lipid peroxidation activities. However, the effects of this plant on human prostate cancer cells have not yet been investiga...

Sequence alignment programs such as BLAST and PSI-BLAST are used routinely in pairwise, profile-based, or intermediate-sequence-search (ISS) methods to detect remote homologies for the purposes of fold assignment and comparative modeling. Yet, the sequence alignment quality of these methods at low sequence identity is not known. We have used the CE structure alignment program (Shindyalov and Bo...

In this paper we discuss the problem of attaining a dynamic compromise between using redundancy to improve software dependability and limiting the amount of redundancy so as to avoid unnecessary inefficiencies. A scheme, called self-configuring optimal programming (SCOP), is developed. SCOP attempts to reduce the resource cost of faulttolerant software, both in space and time, by providing desi...