objective: despite the discovery of new antipsychotic drugs in recent years, a number of schizophrenic patients show no response to such drugs and are considered treatment-resistant. in such cases, clozapine and occasionally ect or a combination of drugs are used, though they are not very effective. in recent years, the combination of clozapine and ect for treatment-resistant schizophrenic pati...

introduction: studies with single photon emission computed tomography (spect) have revealed inconsistent changes of regional cerebral blood flow (rcbf) in schizophrenia. some studies investigated the rcbf and its relationship with psychopathology, positive and negative symptoms in treated patients. however, there is a little information about the pattern of rcbf in recently untreated or never t...

Past literature suggests that schizophrenic men and women may be at different risks for developing different subtypes of schizophrenia. This hypothesis was tested using data from the well-known retrospective cohort family studies, the Iowa 500 and the Iowa non-500. The sample consisted of 171 male and 161 female DSM-III schizophrenic patients and 713 of their first-degree relatives. First, biva...

Middle East Current Psychiatry 2011, 18:72–77 Introduction In Arab countries, epidemiological data about the ways of coping with general day stresses in schizophrenic patients and their quality of life are scarce. This study sought to determine whether there was a difference in ways of coping with stress and quality of life of schizophrenic patients attending the Baljurashi Psychiatric Hospital...

Smoking prevalence for schizophrenic patients is higher than this for general population. More than 60% of schizophrenic patients are current smokers, which contributes to excessive mortality in these patients. The reasons for high frequency of both smoking prevalence and heavy smoking in schizophrenic patients is thought to be at least partially related to enhancement of brain dopaminergic act...

OBJECTIVE It is known that there is a high prevalence of certain anxiety disorders among schizophrenic patients, especially panic disorder and social phobia. However, the neural underpinnings of the comorbidity of such anxiety disorders and schizophrenia remain unclear. Our study aims to determine the neuroanatomical basis of the co-occurrence of schizophrenia with panic disorder and social pho...

Objective: The aim of the present study is to assess information transmission between different cortical areas in schizophrenics by estimating the average cross mutual information (A-CMI) and to characterize the dynamical property of the cortical areas of schizophrenic patients from multi-channel EEG by establishing the auto mutual information (AMI). Methods: We recorded the EEG from 16 electro...

BACKGROUND The electrical signals measuring method is recommended to examine the relationship between neuronal activities and measure with the event related potentials (ERPs) during an auditory and a visual oddball paradigm between schizophrenic patients and normal subjects. The aim of this study is to discriminate the activation changes of different stimulations evoked by auditory and visual E...

OBJECTIVE To test if specific correlations exist between cognitive measures and psychotic dimensions in schizophrenic subjects and if similar correlations, between cognition and schizotypal dimensions, are present in non-psychotic subjects. METHODS We administered the same battery of cognitive tests (Source Monitoring, Verbal Fluency [VF] and Stroop tests) to schizophrenic subjects (N=54), th...

BACKGROUND Schizophrenic patients show deficits in working memory (WM) and inhibition of prepotent responses. We examined brain activity while subjects performed tasks that placed demands on WM and overriding prepotent response tendencies, testing predictions that both processes engage overlapping prefrontal cortical (PFC) regions and that schizophrenic patients show reduced PFC activity and pe...