BACKGROUND Steroids are used in conventional treatment of atopic dermatitis (AD) and they are very effective for improving the symptoms, but they also have several complications. Many studies have reported that short-term use of cyclosporine (CsA) is effective for severe AD as a substitute for steroid. However, there are very few studies on the long-term use of CsA for AD in the Korean populati...

BACKGROUND Environmental pollutants are thought to be one of major triggers of atopic dermatitis (AD). OBJECTIVE We attempted to evaluate the clinical effects of environment with low indoor pollutant levels on AD management. METHODS Fifty-one children (mean age 1.7 years) with moderate to severe AD who failed to show improvement with conventional management were recruited. Disease severity ...

Background In HIV-positive individuals clinicians observe a broad range of skin conditions like xerosis, tumours, rash and drug-induced exanthema as well as common skin infections caused by bacteria, fungi and viruses. Beyond this, some reports point out a higher incidence on atopic conditions like atopic dermatitis (AD), sinusitis, asthma and laboratory findings like hypereosinophilia and Hype...

OBJECTIVE Staphylococcus aureus dominates the skin microbiota in patients with atopic dermatitis (AD), with bacterial loads correlating with disease severity. The aim of this exploratory study was to investigate the effect of a cosmetic lotion containing heat-treated Lactobacillus johnsonii NCC 533 (HT La1) on S. aureus colonization in AD patients. METHODS This open-label, multicenter study w...

INTRODUCTION Mechanisms responsible for UVA1 efficacy in atopic dermatitis (AD) are not fully elucidated. AIM To investigate IL-8, CCR-4, and IFN-γ mRNA expression in AD before and after UVA1, to identify correlations among them, and to determine whether and to what degree mRNA expression is influenced by UVA1. MATERIAL AND METHODS Twenty-five patients with AD underwent medium dose UVA1-pho...

Atopic dermatitis (AD) is a chronic skin disease characterized by defects in the epidermal barrier function and cutaneous inflammation, in which transepidermal water loss (TEWL) is increased and the ability of the stratum corneum to hold water is impaired, causing decreased skin capacitance and hydration. This study investigated the effects of topical virgin coconut oil (VCO) and mineral oil, r...

Atopic dermatitis is a multifactorial chronic inflammatory disease whose unpredictable clinical course is influenced by a complex genetic basis (atopic diathesis) and multiple triggering factors. In adults, atopic dermatitis is characterized by severe pruritus, xerosis, lichenified plaques of eczema, and excoriation. No curative treatment is yet available. Specific immunotherapy with house dust...

Introduction: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D has some roles in immunologic mechanisms. may influence the severity of AD. Previous studies vitamin correlation children with atopic have revealed conflicting results. This study determines between low status children. Methods: cross-sectional analytical approach that involved DA subjects aged ...

BACKGROUND Atopic eczema or dermatitis (AD) is associated with atopy and is characterized by reduced skin hydration and an impaired skin barrier in the epidermis. We investigated the patient acceptability and efficacy of an emollient containing ceramide-precursor lipids and moisturizing factors (LMF) in AD. METHODS Consecutive AD patients were recruited. Swabs and cultures were obtained from ...

BACKGROUND We speculated that an emollient supplemented with a biomass of nonpathogenic bacteria such as Vitreoscilla filiformis (Vf), grown in a medium containing thermal spring water (LRP-TSW); (LRP-Vitreoscilla filiformis biomass [LRP-VFB]), could have a beneficial effect for patients with atopic dermatitis (AD). PATIENTS AND METHODS This double-blind, randomized, comparative study was con...