Protein-protein complexes are known to play key roles in many cellular processes. Therefore, knowledge of the three-dimensional structure of protein-complexes is of fundamental importance. A key goal in protein-protein docking is to identify near-native protein-complex structures. In this work, we address this problem by deriving a knowledge-based scoring function from protein-protein complex s...

this study aimed at investigating the reliability, predictive validity, and self-esteem and gender bias of confidence-based scoring. this is a method of scoring in which the test takers receive a positive or negative point based on their rating of their confidence in an answer. the participants, who were 49 english-major students taking their grammar course, were given 8 multiple-choice tests d...

The performances of several two-step scoring approaches for molecular docking were assessed for their ability to predict binding geometries and free energies. Two new scoring functions designed for "step 2 discrimination" were proposed and compared to our CHARMM implementation of the linear interaction energy (LIE) approach using the Generalized-Born with Molecular Volume (GBMV) implicit solvat...

Objectives: To evaluate the impact of correction of stress urinary incontinence (SUI) using either Transobturator tape (TOT) or Tension-free vaginal tape (TVT) procedure on females’ sexual function. Patients and Methods: The study included 80 women with SUI; 40 underwent TVT and 40 underwent TOT and completed preoperative Pelvic Organ Prolapse/Urinary Incontinence Sexual Function Questionnaire ...

Prediction of functional peptide motifs from sequences is an important problem in bioinformatics. Experimental discovery of functional sequences is laborious. Searches for specific motifs within the increasing number of proteins available in public databases often involve extensive computer calculations. Short peptide motifs are especially hard to identify via currently available methods. Prese...

In the present study, the antimicrobial tests of patchouli oil were studied by using molecular docking technology and antimicrobial test in vitro. Five biological macromolecule enzymes, required by the bacteria in the process of biosynthesis were selected as target molecules. Five antibiotics benzylpenicillin, sulfadiazine, trimethoprim, rifampicin and ciprofloxacin, which are generally acknowle...

In the present study, the antimicrobial tests of patchouli oil were studied by using molecular docking technology and antimicrobial test in vitro. Five biological macromolecule enzymes, required by the bacteria in the process of biosynthesis were selected as target molecules. Five antibiotics benzylpenicillin, sulfadiazine, trimethoprim, rifampicin and ciprofloxacin, which are generally acknowle...

The studies conducted so far on the effectiveness of resolution methods including the discussion method in resolving discrepancies in rating have yielded mixed results. What is left unnoticed in the literature is the potential of discussion to be used as a training tool rather than a resolution method. The present study addresses this research gap by exploring the data coming from rating behavi...

Tandem mass spectrometry (MS/MS) has become a standard way for identifying peptides and proteins. A scoring function plays an important role in the MS/MS data analysis. De novo sequencing is the computational step to derive a peptide sequence from an MS/MS spectrum, normally by constructing the peptide that maximizes the scoring function. A number of polynomial time algorithms have been develop...

Computational prediction of RNA-protein complex 3D structures includes two basic steps: one is sampling possible structures and another is scoring the sampled structures to pick out the correct one. At present, constructing accurate scoring functions is still not well solved and the performances of the scoring functions usually depend on used benchmarks. Here we propose a pair-conformation-depe...