INTRODUCTION Scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (AMPs) have been found in the venom gland of scorpions. Therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. Here, we describe three new cationic AMPs, including meuVAP-6, meuAP-18-1, and meuPep34 from the ven...

this epidemiological review was carried out to display the magnitude and the geographic distribution of scorpion envenomation in iran with focus on the southwestern region of iran, particularly. the iranian recognized scorpions belonging to two families, including buthidae and scorpionidae. buthidae family consists of 14 genuses, 26 species, and 18 sub-species, while scorpionidae family has thr...

Buthotus schach Finally, according to our results venom as well as fractions F4 and F6 act mostly prejunctionally on Ach release. More attempt is carrying out to study their effects on ion channel activities. is one of the most dangerous scorpions in tropical part of Iran. The effects of its crude venom at 1, 3, 10 µg/mL and its obtained fractions by gel filtrations were investigated on neuromu...

hemiscorpius lepturus is medically important scorpion species present in the south and southwest part of iran, causing morbidity and mortality in children and adults. unlike other scorpions studied so far, the venom of h. lepturus is highly cytotoxic, that can be a reason for its complexity in clinical manifestations in patients stung by this scorpion. scarce studies showed the mechanism involv...

in tropical and subtropical countries, envenomation by scorpions (so-called scorpionism) represents a serious public health problem. in the present study, the toxic effects of mice ld50 injections of mesobuthus eupeus (me) venom on the kidney and liver of anesthetized rabbits were investigated. six rabbits were selected and alt, ast, bun and creatinine were measured at 0, 1 and 3 hours after...

INTRODUCTION Infrared imaging (IR) is a noninvasive technique that quantifies body surface temperature, producing a digital color image. IR has been used to study diseases in which skin temperature can reflect the presence of inflammation. METHODS This was an observational pilot study of eight patients envenomed by snakes, spiders, and scorpions. All patients were examined using a thermal cam...

Spiders, scorpions, and cone snails are remarkable for the extent and diversity of gene-encoded peptide neurotoxins that are expressed in their venom glands. These toxins are produced in the form of structurally constrained combinatorial peptide libraries in which there is hypermutation of essentially all residues in the mature-toxin sequence with the exception of a handful of strictly conserve...

Scorpion venom toxicity is of major concern due to its influence on human activities and public health. We investigated the in-vitro process of cell death caused by two Iranian scorpions Odontobuthus doriae and Bothutus salceyi venom on human cell lines. The aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...

  Scorpion venoms contain of variety of peptides toxic to mammals ، insects and crustaceans. Toxic peptides are the main factors in scorpion venom causing toxicity, (their amount being 1-3%of total venom.). Most of the scorpion toxins have been isolated from the venoms of scorpions in the family Buthidae. The scorpion Buthotus Schach belonging to the Buthidae family is widely found in the weste...