Neuroprotective effect of the extract from aerial parts of Scrophularia striata Boiss (Scrophulariaceae) was investigated against glutamate-induced neurotoxicity on cultured rat pups Cerebellar Granule Neurons (CGNs). CGNs from 8 days old Sprague-Dawley rat were prepared and cultured. The experiments were performed after 8 days in culture. The plant was collected from the northeastern part (Rui...

Two polyacetylene glycosides, gymnasterkoreasides A and B, were isolated from the roots of Gymnaster koraiensis. Their structures were elucidated to be (3R)-8-decene-4,6-diyne-1,3-diol 1-O-beta-D-glucopyraside and (3R)-8-decene-4,6-diyne-1,3-diol 1-O-beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyraside on the basis of spectroscopic analysis including COSY, HMQC, and HMBC experiments, as well as ch...

Five iridoid glycosides, including the two new compounds scropolioside-D(2) (1) and harpagoside-B (2), were isolated from the aerial parts of Scrophularia deserti DEL (Scrophulariaceae). Their structures were elucidated on the basis of spectral data to be 6-O-[2",4"-di-O-acetyl-3"-O-trans-cinnamoyl)-alpha-L-rhamnopyranosyl]-8 alpha-hydroxymethyl-1 alpha,5 beta,6 alpha,7 alpha,9 beta-pentahydro-...

BACKGROUND We evaluated the effect of the ethanolic extract of Scrophularia striata on the Iranian strain of Leishmania major (MRHO/IR/75/ER) both in vitro and in vivo conditions. METHODS The effective dose (ED) of ethanolic extract of S. striata were determined using MTT assay on the growth of promastigote forms of L. major in axenic culture media. Then, the ED50 of S. striata on mice perito...

Background: Myocardial infarction (MI) is the leading cause of death among cardiovascular diseases. Reperfusion, most harmful phase, accompanied by inflammatory, oxidative, and apoptotic cascades in cardiomyocytes, impairing hemodynamic histologic status cardiac tissue. The Scrophularia genus well known for cardioprotective effects its species, showing beneficial impacts on blood pressure arrhy...

Min-Wook Kim, M.D., Dae-Hyun Jang, M.D., Jun Kang, M.D., Seungok Lee, M.D., Sun Young Joo, M.D., Ja-Hyun Jang, M.D., Eun-Hae Cho, M.D., Young-Chul Choi, M.D., and Jung Hwan Lee, M.D. Departments of Rehabilitation, Hospital Pathology, Laboratory Medicine, and Orthopaedic Surgery, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul; Green Cross Genome, Yongin...

In the present study, seed surface ornamentations in 31 species (34 populations) and the capsule surface sculpturing in five species of the genus Scrophularia L. distributed in Iran were examined using Scanning Electronic Microscopy. Based on the published seed surface terminologies, all examined seeds show the reticulate pattern with scalariform inner ornamentations. However, there is enough b...