Sebaceous glands (SGs) undergo cyclic renewal independent of hair follicle stem cells (HFSCs) activation while HFSCs have the potential to differentiate into sebaceous gland cells, hair follicle and epidermal keratinocytes. Abnormalities of sebaceous gland progenitor cells contribute to the development of sebaceous neoplasms, but little is known about the role of HFSCs during sebaceous neoplasm...

Lipoprotein delivery of fatty acids and cholesterol is linked with peroxisome proliferator-activated receptor (PPAR) activation in adipocytes and macrophages. We postulated that similar interactions exist in sebaceous epithelial cells (sebocytes) in which PPAR activation induces differentiation. High-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) markedly enhanced sebocyte di...

BACKGROUND Recent studies have demonstrated telomerase expression in ophthalmologic sebaceous carcinoma and have suggested possible diagnostic utility in distinguishing these neoplasms from sebaceous adenomas. The aim of this study was to evaluate telomerase expression via human telomerase reverse transcriptase (hTERT) immunohistochemical staining in a spectrum of sebaceous lesions of the skin....

IMPORTANCE The molecular-genetic alterations contributing to the pathogenesis of sebaceous carcinoma and sebaceous adenoma remain poorly understood. Given that sebaceous carcinoma is associated with substantial morbidity and mortality, there is a critical need to delineate the pathways driving sebaceous carcinoma and candidate molecules for targeted therapy. OBJECTIVE To describe differential...

BACKGROUND Sebaceous carcinoma is notorious for masquerading clinically as other benign lesions such as chalazion. A tool to better differentiate between these two conditions would thus be desirable. PURPOSE To examine the potential application of noninvasive meibography in the differential diagnosis of chalazion and sebaceous carcinoma of the eyelid as a retrospective cross-sectional study. ...

Figure Legend: Figure 1 Oral mucosa, Gingiva Ectopic tissue, Sebaceous gland in male F344/N rat from a chronic study. There are clusters of sebaceous glands in the gingiva. Figure 2 Oral mucosa, Gingiva Ectopic tissue, Sebaceous gland in male F344/N rat from a chronic study (higher magnification of Figure 1). The clusters of sebaceous glands in the gingiva are adjacent to a dilated duct. Figure...

516 Ann Dermatol Received April 28, 2016, Revised August 9, 2016, Accepted for publication August 22, 2016 Corresponding author: Ji Yeon Byun, Department of Dermatology, Ewha Womans University Mokdong Hospital, 1071 Anyangcheon-ro, Yangcheongu, Seoul 07985, Korea. Tel: 82-2-2650-5160, Fax: 82-2-2652-6925, E-mail: [email protected] This is an Open Access article distributed under the terms of th...