Eccrine porocarcinoma is a rare malignant skin tumor that often presents as the transformation of an underlying poroma. Nevus sebaceous benign hamartoma, from which various secondary neoplasm may arise. Since these tumors arise long-standing precursor lesions, multi-sampling, genomic analysis provide us with insight into life history tumors. Whole exome sequencing showed high intra-tumor hetero...

RATIONALE Linear nevus sebaceous syndrome (LNSS) is a rare neurocutaneous syndrome, characterized by nevus sebaceous,central nervous system (CNS), ocular and skeletal abnormalities. The present study describes KRAS somatic mosaic mutation in a case of LNSS with lymphatic malformations (LMs). PATIENT CONCERNS A 4-month-old female with a clinical diagnosis of LNSS presented with infantile spasm...

Apocrine nevus is a rare benign tumor of which only 9 cases have been reported in the literature. The apocrine nevus is seen mostly in the areas where the apocrine glands are normally distributed such as axillae, head and neck. Our case was a 16-year old girl who referred with a verrucous erythematous plaque over right parietal side of the scalp. The patient had the plaque since birth with part...

Syringocystadenoma papilliferum (SCAP) is an uncommon benign adnexal tumor of the skin. It is frequently seen in association with other benign adnexal lesions, such as nevus sebaceous, apocrine nevus, tubular apocrine adenoma, apocrine hidrocystoma, apocrine cystadenoma, and clear cell syringoma. The unusual reported locations of SCAP include the head and neck, the buttock, the vulva, the scrot...

Nevus lipomatosus superficialis (NLS) is an uncommon hamartomatous lesion of the skin characterized by the presence of clusters of mature fat cells among the collagen bundles of the dermis. Usually, the number of adnexal structures is reduced in NLS as compared to the normal adjacent skin, but their morphology is not altered. Nevertheless, in some instances, associated pilar abnormalities have ...

A Japanese baby was born with a polypoidal projection with hair, on the lateral corner of upper eyelid. The tumour had extent to bulbar sub-conjunctival area. He presented no other malformation nor pathological symptoms. There was no sign of association with Goldenhar, hemifacial macrosomia, epidermal nevus or linear nevus sebaceous syndromes. The tumour was resected at his age of 4 months. The...