Highly promising fully biobased random copolyesters, poly(trimethylene 2,5-furandicarboxylate-co-trimethylene sebacate) (PTFcoPTSeb), were synthesized by using bio derived 1,3-propanediol, dimethyl ester of 2,5- furandicarboxylic acid, and sebacic through eco-friendly polycondensation in the melt. Copolymers with high molecular weight containing 5, 15, 25 mol % PTSeb obtained, their chemical st...

Thermoplastic polymers are currently prepared almost exclusively from fossil feedstocks. In view of the limited availability of such feedstocks, alternative renewable resources are desirable in the long term.[1.2] Polymer production from a renewable resource ideally allows for a complete molecular utilization of the feedstock and carries its molecular structure over into the resulting polymers,...

Poly(glycerol sebacate) (PGS) continues to attract attention for biomedical applications owing its favorable combination of properties. Conventionally polymerized by a two-step polycondensation glycerol and sebacic acid, variations synthesis parameters, reactant concentrations or specific chemical modifications, PGS materials can be obtained exhibiting wide range physicochemical, mechanical, mo...

The research was performed to study the simultaneous detection of a homologous series of α , ω -dicarboxylic acids (C2-C10), oxalic, malonic, succinic, glutaric, adipic, pimelic, suberic, azelaic, and sebacic acids, with capillary electrophoresis using indirect UV detection. Good separation efficiency in 2,6-pyridinedicarboxylic acid as background electrolyte modified with myristyl trimethyl am...

Stroke is a leading cause of disability with no effective regenerative treatment. One promising strategy for achieving tissue repair involves the stimulation of endogenous neural stem/progenitor cells through sequential delivery of epidermal growth factor (EGF) followed by erythropoietin (EPO). Yet currently available delivery strategies such as intracerebroventricular (ICV) infusion cause sign...

This paper will introduce dihydrazides, a relatively obscure class of curing agents useful in virtually all thermoset resin systems. First described in 1958, by Wear, et al. dihydrazides are useful curing agents for epoxy resins, chain extenders for polyurethanes, and excellent crosslinking agents for acrylics. In one-part epoxy systems, depending on the backbone chain of the chosen dihydrazide...

AIM To investigate the impact of chronic ingestion of sebacic acid (SA), a 10-carbon medium-chain dicarboxylic acid, on glycaemic control in a mouse model of type 2 diabetes (T2D). METHODS Three groups of 15 db/db mice were fed for 6 weeks either a chow diet (Ctrl) or a chow diet supplemented with 1.5 or 15% (SA(1.5%) and SA(15%) , respectively) energy from SA. Fasting glycaemia was measured ...

Protective mucus coatings typically trap and rapidly remove foreign particles from the eyes, gastrointestinal tract, airways, nasopharynx, and female reproductive tract, thereby strongly limiting opportunities for controlled drug delivery at mucosal surfaces. No synthetic drug delivery system composed of biodegradable polymers has been shown to penetrate highly viscoelastic human mucus, such as...

Polyester synthesis activity of immobilized Humicola insolens (HiC) was systematically studied with three-series of substrates varying in (i) omega-hydroxyalkanoic acid (omegaHA), (ii) alpha,omega-n-alkane diol, and (iii) alpha,omega-n-alkane diacid chain length. Covalent immobilization of HiC on Amberzyme oxirane (AO) resin (i.e., AO-HiC) was prepared. HiC-AO's activity for omegaHA substrates ...

Polyanhydride copolymers based on 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic acid (SA) are bioerodible, semicrystalline polymers that have been used for drug delivery. In addition to their semicrystallinity, these materials also exhibit microphase separation in the amorphous phase. This complex phase behavior, combined with the disparity in the erosion rates of the two different chemical...