A direct and an efficient conversion of a wide range of primary, secondary even tertiary alcohols to the corresponding iodides have been achieved under ionic liquid conditions. The method involves preparation of ionic liquid-based iminium chloride intermediate from DMF-like ionic liquid then stirring it with alcohol in present of sodium iodide. The higher yields of alkyl iodides were obtained w...

Sulfuric acid ([3-(3-silicapropyl)sulfanyl]propyl]ester (SASPSPE) is employed as a recyclable catalyst for the silylation of hydroxyl groups. A good range of primary, secondary alcohols and phenolic hydroxyl groups were effectively converted into their corresponding trimethylsilyl ethers with hexamethyldisilazane in the presence of catalytic amounts of SASPSPE at room temperature with short rea...

The non-enzymatic acylative kinetic resolution of challenging aryl-alkenyl (sp2 vs. sp2 ) substituted secondary alcohols is described, with effective enantiodiscrimination achieved using the isothiourea organocatalyst HyperBTM (1 mol %) and isobutyric anhydride. The kinetic resolution of a wide range of aryl-alkenyl substituted alcohols has been evaluated, with either electron-rich or naphthyl ...

An efficient and simple method for selective oxidation of secondary alcohols and oxidation of alkanes to ketones is reported. An in situ prepared catalyst is employed based on manganese(II) salts, pyridine-2-carboxylic acid, and butanedione, which provides good-to-excellent conversions and yields with high turnover numbers (up to 10 000) with H2 O2 as oxidant at ambient temperatures. In substra...

From the standpoint of enzymatic organic synthesis, NADH oxidase (NOX) will be a key enzyme that plays an essential role in the cofactor regeneration of NAD+ dependent enzymatic reactions. For example, enzymatic enantioselective oxidations of racemic secondary alcohols (Geueke et al., 2003; Riebel et al., 2003; Hummel & Riebel, 1996) and amino acids (Hummel et al., 2003a) have been reported as ...

The catalase-ethyl hydrogen peroxide compound studied by Stern (1) formed slowly, even in the presence of a very large concentration of ethyl hydrogen peroxide. In the previous paper (2), Stern’s compound has been shown to be preceded by a green primary compound. These kinetic studies show that the primary compound forms rapidly, has a high affinity* for its substrate, and quantitatively fulfil...

The catalase-ethyl hydrogen peroxide compound studied by Stern (1) formed slowly, even in the presence of a very large concentration of ethyl hydrogen peroxide. In the previous paper (2), Stern’s compound has been shown to be preceded by a green primary compound. These kinetic studies show that the primary compound forms rapidly, has a high affinity* for its substrate, and quantitatively fulfil...

An enantioselective asymmetric reduction of phenyl ring-containing prochiral ketones toyield the corresponding optically active secondary alcohols was achieved with W110Asecondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus (W110A TeSADH) inTris-HCl buffer using 2-propanol (30%, v/v) as cosolvent and cosubstrate. This concentration of2-propanol was crucial not only...

The enantioselective oxidation of secondary alcohols represents a valuable approach for the synthesis optically pure compounds. Flavoprotein oxidases can catalyse such selective transformations by merely using oxygen as electron acceptor. While many flavoprotein preferably act on primary alcohols, FAD-containing alcohol oxidase from Phanerochaete chrysosporium was found to be able perform kinet...

In this article, the catalytic activity of bis[2-(p-tolyliminomethyl)phenolato] copper(II) complex was studied, for the first time, in the oxidation of various primary and secondary alcohols to the corresponding aldehydes or ketones. The effect of different solvent was studied in the oxidation of benzyl alcohol and methanol was chosen as the reaction medium. Also the effect of different oxidant...