Solar lentigo (SL) is a common hyperpigmented lesion occurring on sun-exposed skin, and sign of photodamage aging. WNT/β-catenin signaling promotes melanogenesis via activating MITF, the master regulator melanocytes. Secreted frizzled related proteins (sFRP) are antagonists that inhibit binding WNT ligands to their receptors. However, recent studies have reported sFRP2 activates melanocytes, su...