This study evaluated the sedative, and anticonvulsant activities of aqueous (AESM) ethanol (EESM) dried leaf extracts Solenostemon monostachyus. The sedative effect was with ketamine-induced hypnosis (100 mg/kg, i.p.). Also, activity using pentylenetetrazole (PTZ)-induced convulsion (85 i.p.), strychnine-induced (2 i.p.) maximal electroshock (MES)-induced models. AESM (200 p.o.) gave 66.67% pro...

The elderly use drugs more commonly than younger persons. Many studies about drug use have concentrated on institutionalized elders. Knowledge of drug use by the oldest old, aged 85 years or over, is scant. Psychotropics are among the drugs most commonly used by the elderly. Psychotropics have many adverse effects, such as balance impairment, sedation, reduced cognition, depression, and extrapy...

AIM To investigate methanol extracts of various parts of Rubus fruticosus L. (Rosaceae) for various neuropharmacological activities, such as anxiolytic, muscle relaxant, antidepressant, and sedative activities. MATERIALS AND METHODS The extracts were administered to albino mice orally at doses of 100, 300, and 500 mg/kg. The antidepressant activity was determined by using the forced swimming ...

In pediatric dentistry, chloral hydrate is habitually selected for sedation of uncooperative children. Although chloral hydrate has been used for decades, various adverse effects are reported and necessity for new alternative drugs has increased. Dexmedetomidine was approved by FDA for sedation at intensive care units (ICU) in 1999. Compared to conventional sedative drugs, dexmedetomidine has n...