This study was designed to determine the effect of inhibitors of cyclooxygenase (COX)-1, COX-2, and the nonselective COX inhibitor naproxen on coronary vasoactivity and thrombogenicity under baseline and lipopolysaccharide (LPS)-induced inflammatory conditions. We hypothesize that endothelial COX-1 is the primary COX isoform in the canine normal coronary artery, which mediates arachidonic acid ...

The cyclooxygenase (COX) inhibitors are the most common drugs used worldwide. COX corresponds to an evolutionarily conserved class of enzymes and has two main isoforms: COX-1, which is largely associated with physiological functions, and COX-2, which is largely associated with pathological functions. Their subproducts have an important role in inflammation and pain perception. The COX-2 selecti...

Previous studies have suggested a possible role for prostaglandins (PGs) in mediating alterations in nephron structure and function ensuing after renal ablation. Two isoforms of cyclooxygenase (COX) have been described: constitutive (COX-1) and inducible (COX-2). We examined expression of these isoforms following subtotal renal ablation (5/6 ablation, RA) in rats. In renal cortex, COX-2 mRNA an...

BACKGROUND Cyclooxygenase (COX) activity is induced in human atherosclerosis, and the products formed may modify the disease directly or through an effect on platelets. We examined the role of COX-1 and -2 on platelet vessel wall interactions and development of atherosclerosis in a murine model. METHODS AND RESULTS Apolipoprotein E-deficient (apoE-/-) mice fed a 1% cholesterol diet were treat...

Concern is growing about an increased risk of thrombotic events (including myocardial infarction and stroke) during the use of non-steroidal antiinflammatory drugs (NSAIDs), in particular the so called selective cyclo-oxygenase-2 (COX 2) inhibitors. Although clinical trials give conflicting results with respect to the incidence of vascular events, increasing evidence shows that a class effect m...

This study was designed to determine the effect of inhibitors of COX-1, COX-2 and the nonselective COX inhibitor, naproxen on, coronary vasoactivity and thrombogenicity under baseline and lipopolysaccharide-induced inflammatory conditions. We hypothesize that; endothelial COX-1 is the primary COX isoform in the canine normal coronary artery, which mediates arachidonic acid-induced vasodilatatio...