Thiosemicarbazone analogs of papaveraldine and related compounds 1-6 were synthesized and evaluated for cytotoxic and antimalarial activities. The cytotoxic activity was tested against HuCCA-1, HepG2, A549 and MOLT-3 human cancer cell lines. Thiosemicarbazones 1-5 displayed cytotoxicity toward all the tested cell lines, while compounds 2-5 selectively showed potent activity against the MOLT-3 c...

Isatin is an endogenous compound identified in humans that possesses a wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activities and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and scSTY tests. Various isatin-N-Mannich bases of ...

Preparation of bisbenzofuran-2-yl-methanone (1), the corresponding ketoxime 4, semicarbazone and thiosemicarbazone 3a and 3b, ether derivatives of the ketoximes 5a-j and the alcohol 2 are described. These substances have been prepared in excellent yields. All the synthesized compounds except 5i have been tested against five different microorganisms and some of them were found to be active again...

Cu (II) and Ni (II) complexes of general composition [ML2]X2 (M = Cu(II), Ni(II); X = Cl, NO3) were synthesized by the condensation of metal salts with semicarbazone / thiosemicarbazone derived from pdimethylaminobanzaldehyde. The metal complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, IR and atomic absorption spectral studies. On the b...

In the title complex, [Cd(C12H11N4S2)I(C12H12N4S2)], the Cd(II) ion is penta-coordinated by two thio-semicarbazone ligands (one neutral and the other anionic) and one iodide ion in a distorted square pyramidal (τ = 0.35) geometry. The central ion is coordinated by the thia-zole N atom, the thio-ureido N and the S atom of the deprotonated thio-semicarbazone ligand. The other ligand is linked wit...

A spectrophotometric method has been developed for the determination of Cu(II) using Acetophenone 2’,5’dihydroxy, semicarbazone as an extractive reagent .The reagent forms a colored complex which has been quantitatively extracted into n-Butanol at pH 5.6. The method obeys Beer’s law over a range of 1 to 10 ppm. The molar absorptivity is 2564.1 L molcm and Sandell’s sensitivity is 0.02484 μg cm ...

Mixed ligand complexes of indium (111) have been synthesized by the reaction of InCl3.6H2O with semicarbazone (SCH) and benzaldazine (BA) ligands in neutral and basic medium. Complexes of the type [In2 (BA)2 (LH)4]Cl6 and [In2 (BA)2 (L)4]Cl2 (where BA = benzaldazine, LH = semicarbazone ligands (SCH) and L = deprotonated semicarbazone ligands (SC)) have been proposed in neutral and basic medium,...

In 1942 Wiesner (1) and Waksman, Horning, and Spencer (2) demonstrated that filtrates from cultures of Aspergillus clavatus grown upon synthetic media possess antibiotic activity. These investigators extracted and partially purified the active material (which was named clavacin by Waksman) but did not report its isolation in pure form. As a result of the observations made by Waksman’s group, pa...