Decision making ability has been reported to be impaired in schizophrenia patients, but no research has examined the genetic bases of this impairment. This study investigated how decision making was affected by the genetic variants in the serotonin transporter gene (triallelic 5- HTTLPR) and serotonin receptor 1A gene (rs6295) and their interaction in 465 schizophrenia patients and 448 healthy ...

BACKGROUND Tramadol-induced seizures might be pathologically associated with serotonin syndrome. Here, the authors investigated the relationship between serotonin and the seizure-inducing potential of tramadol. METHODS Two groups of rats received pretreatment to modulate brain levels of serotonin and one group was treated as a sham control (n = 6 per group). Serotonin modulation groups receiv...

Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a peripheral hormone. Most of the body's serotonin is circulating in the bloodstream, transported by blood platelets and is released upon activation. The functions of serotonin are mediated by members of the 7 known mammalian serotonin receptor subtype classes (15 known subtypes), the serotonin transporter (SERT), ...

The behavioral plasticity of locusts is a striking trait presented during the reversible phase transition between solitary and gregarious individuals. However, the results of serotonin as a neurotransmitter from the migratory locust Locusta migratoria in phase transition showed an alternative profile compared to the results from the desert locust Schistocerca gregaria. In this study, we investi...

5-Hydroxyindoleacetic acid (5-HIAA) is a major metabolite of serotonin, generated via a two step process, involving monoamine oxidase A (MAO-A) and aldehyde dehydrogenase. Measurement of 5HIAA in combination with serotonin may offer insight into mechanisms underlying various clinical symptoms. The ratio of serotonin to 5-HIAA may be used to evaluate serotonin turnover and monoamine oxidase acti...

Serotonin (5-hydroxytryptamine, 5-HT) can stimulate the lower esophageal sphincter (LES) by indirect actions on the modulation of reflexes and by a direct action on smooth muscles. Aim:of this study was to investigate the role of 5-HT and selective 5-HT receptor subtypes in the regulation of the lower esophageal sphincter (LES) in the rat by measuring electromotor activity of the LES. Methods:T...

The entorhinal cortex (EC) is considered as the gate to control the flow of information into and out of the hippocampus. The EC is important for numerous physiological functions such as emotional control, learning and memory and pathological disorders including Alzheimer's disease, schizophrenia and temporal lobe epilepsy. Serotonin is a classical neurotransmitter which may modify these physiol...

In vivo microdialysis was performed in wildtype and 5-HT1B receptor knockout mice to explore the role of 5-HT1B receptors in striatal serotonin (5-HT) and dopamine (DA) outflow. Local administration of the selective 5-HT reuptake inhibitor fluvoxamine (0.1 – 10 μM) dose-dependently increased 5-HT to the same extent in wildtype and 5-HT1B receptor knockout mice. The 5-HT1B receptor agonist CP931...